Transgenic animal models of congenital diaphragmatic hernia: a comprehensive overview of candidate genes and signaling pathways.
Congenital diaphragmatic hernia
Lung development
Pulmonary hypertension
Pulmonary hypoplasia
Retinoic acid
Transgenic mice
Journal
Pediatric surgery international
ISSN: 1437-9813
Titre abrégé: Pediatr Surg Int
Pays: Germany
ID NLM: 8609169
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
accepted:
17
06
2020
pubmed:
28
6
2020
medline:
29
12
2020
entrez:
28
6
2020
Statut:
ppublish
Résumé
Congenital diaphragmatic hernia (CDH) is a relatively common and life-threatening birth defect, characterized by incomplete formation of the diaphragm. Because CDH herniation occurs at the same time as preacinar airway branching, normal lung development becomes severely disrupted, resulting almost invariably in pulmonary hypoplasia. Despite various research efforts over the past decades, the pathogenesis of CDH and associated lung hypoplasia remains poorly understood. With the advent of molecular techniques, transgenic animal models of CDH have generated a large number of candidate genes, thus providing a novel basis for future research and treatment. This review article offers a comprehensive overview of genes and signaling pathways implicated in CDH etiology, whilst also discussing strengths and limitations of transgenic animal models in relation to the human condition.
Identifiants
pubmed: 32591848
doi: 10.1007/s00383-020-04705-0
pii: 10.1007/s00383-020-04705-0
pmc: PMC7385019
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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