AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow.
AMPK
intrauterine growth restriction
pregnancy
uterine artery
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
20
11
2019
accepted:
24
06
2020
pubmed:
28
6
2020
medline:
16
2
2021
entrez:
28
6
2020
Statut:
ppublish
Résumé
Pregnancy at high altitude is associated with a greater incidence of fetal growth restriction due, in part, to lesser uterine artery blood flow. AMP-activated protein kinase (AMPK) activation vasodilates arteries and may increase uterine artery blood flow. In this study, pharmacological activation of AMPK by the drug AICAR improved fetal growth and elevated uterine artery blood flow. These results suggest that AMPK activation is a potential strategy for improving fetal growth and raising uterine artery blood flow in pregnancy, which may be important in pregnancy disorders characterized by uteroplacental ischaemia and/or fetal hypoxia. Uteroplacental hypoxia is associated with pregnancy disorders such as intrauterine growth restriction and preeclampsia, which are characterized by uteroplacental ischaemia and/or fetal hypoxia. Activation of AMP-activated protein kinase (AMPK) results in vasodilatation and is therefore a potential therapeutic strategy for restoring uteroplacental perfusion in pregnancy disorders. In this study, C57Bl/6 mice were treated with subcutaneous pellets containing vehicle, the AMPK activator AICAR (200 mg kg
Identifiants
pubmed: 32592403
doi: 10.1113/JP279341
pmc: PMC7749723
mid: NIHMS1620701
doi:
Substances chimiques
Ribonucleotides
0
Aminoimidazole Carboxamide
360-97-4
AMP-Activated Protein Kinases
EC 2.7.11.31
AICA ribonucleotide
F0X88YW0YK
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4093-4105Subventions
Organisme : NICHD NIH HHS
ID : R01 HD088590
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138181
Pays : United States
Organisme : FIC NIH HHS
ID : R21 TW010797
Pays : United States
Organisme : NIH HHS
ID : S10 OD018156
Pays : United States
Informations de copyright
© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society.
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