Evaluation of a new collagen-based medical device (ElastiCo®) for the treatment of acute Achilles tendon injury and prevention of peritendinous adhesions: An in vitro biocompatibility and in vivo investigation.
Achilles tendon
collagen
in vivo study
peritendinous adhesions
rats
suture
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
22
11
2019
revised:
05
05
2020
accepted:
01
06
2020
pubmed:
28
6
2020
medline:
12
8
2021
entrez:
28
6
2020
Statut:
ppublish
Résumé
Tendon healing still represents a challenge for clinicians because it is slow and incomplete. The most injured is the Achilles tendon, and surgery is the therapeutic strategy often adopted because it provides a quicker functional recovery. Peritendinous adhesions are the main complication of surgery with hyperplasia and chemotaxis of fibroblasts. A biomaterial that blocks fibroblast migration, without interfering with the passage of cytokines and growth factors, might be useful. The present study evaluated the biocompatibility of a new Type I collagen-based scaffold (ElastiCo®) and its ability to promote Achilles tendon healing, inhibiting adhesion formation. After verifying in vitro biocompatibility, physical, and mechanical properties of the scaffold, an in vivo study was performed in 28 rats, operated to induce an acute lesion in both Achilles tendons. One tendon was treated with the suture only and the contralateral one with suture wrapped with ElastiCo® film. After 8 and 16 weeks, it was observed that ElastiCo® reduced internal and external peritendinous adhesions and Collagen III content and increased Collagen I. Elastic modulus increased with both treatments over time. Current results highlighted the clinical translationality of ElastiCo® that could improve the quality of life in patients affected by Achilles tendon lesions surgically treated.
Substances chimiques
Biocompatible Materials
0
Collagen
9007-34-5
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1113-1125Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
Bellini, D., Cencetti, C., Sacchetta, A. C., Battista, A. M., Martinelli, A., Mazzucco, L., … Matricardi, P. (2016). PLA-grafting of collagen chains leading to a biomaterial with mechanical performances useful in tendon regeneration. Journal of the Mechanical Behavior of Biomedical Materials, 64, 151-160. https://doi.org/10.1016/j.jmbbm.2016.07.006
Black, D. A., Lindley, S., Tucci, M., Lawyer, T., & Benghuzzi, H. (2011). A new model for repair of the Achilles tendon in the rat. Journal of Investigative Surgery, 24, 217-221. https://doi.org/10.3109/08941939.2011.575915
Bottagisio, M., & Lovati, A. B. (2017). A review on animal models and treatments for the reconstruction of Achilles and flexor tendons. Journal of Materials Science: Materials in Medicine, 28, 45. https://doi.org/10.1007/s10856-017-5858-y
Buschmann, J., Calcagni, M., Bürgisser, G. M., Bonavoglia, E., Neuenschwander, P., Milleret, V., & Giovanoli, P. (2015). Synthesis, characterization and histomorphometric analysis of cellular response to a new elastic DegraPol® polymer for rabbit Achilles tendon rupture repair. Journal of Tissue Regenerative Medicine, 9, 584-594. https://doi.org/10.1002/term.1624
Buschmann, J., Puippe, G., Burgisser, G. M., Bonavoglia, E., Giovanoli, P., & Calcagni, M. (2014). Correspondence of high-frequency ultrasound and histomorphometry of healing rabbit Achilles tendon tissue. Connective Tissue Research, 55, 123-131. https://doi.org/10.3109/03008207.2013.870162
Chamberlain, C. S., Lee, J. S., Leiferman, E. M., Maassen, N. X., Baer, G. S., Vanderby, R., & Murphy, W. L. (2015). Effects of BMP-12-releasing sutures on Achilles tendon healing. Tissue Engineering Part A, 21, 916-927. https://doi.org/10.1089/ten.TEA.2014.0001
Chen, E., Yang, L., Ye, C., Zhang, W., Ran, J., Xue, D., … Hu, Q. (2018). An asymmetric chitosan scaffold for tendon tissue engineering: in vitro and in vivo evaluation with rat tendon stem/progenitor cells. Acta Biomaterialia, 73, 377-387. https://doi.org/10.1016/j.actbio.2018.04.027
Chen, J. L., Yin, Z., Shen, W. L., Chen, X., Heng, B. C., Zou, X. H., & Ouyang, H. W. (2010). Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials, 31, 9438-9451. https://doi.org/10.1016/j.biomaterials.2010.08.011
Chen, Q., Lu, H., & Yang, H. (2014). Chitosan inhibits fibroblasts growth in Achilles tendon via TGF-β1/Smad3 pathway by miR-29b. International Journal of Clinical and Experimental Pathology, 7, 8462-8470.
Cook, J. L., Feller, J. A., Bonar, S. F., & Khan, K. M. (2004). Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons. Journal of Orthopedic Research, 2, 334-338.
Dabak, T. K., Sertkaya, O., Acar, N., Donmez, B. O., & Ustunel, I. (2015). The effect of phospholipids (surfactant) on adhesion and biomechanical properties of tendon: A rat Achilles tendon repair model. BioMed Research International, 2015, 689314. https://doi.org/10.1155/2015/689314
Del Buono, A., Volpin, A., & Maffulli, N. (2014). Minimally invasive versus open surgery for acute Achilles tendon rupture: A systematic review. British Medical Bulletin, 109, 45-54. https://doi.org/10.1093/bmb/ldt029
Derwin, K. A., Baker, A. R., Spragg, R. K., Leigh, D. R., & Iannotti, J. P. (2006). Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties. The Journal of Bone and Joint Surgery, 88, 2665-2672. https://doi.org/10.2106/00004623-200612000-00014
Gulati, V., Jaggard, M., Al-Nammari, S. S., Uzoigwe, C., Gulati, P., Ismail, N., … Gupte, C. (2015). Management of Achilles tendon injury: A current concepts systematic review. World Journal of Orthopedics, 6, 380-386. https://doi.org/10.5312/wjo.v6.i4.380
Kraeutler, M. J., Purcell, J. M., & Hunt, K. J. (2017). Chronic Achilles tendon ruptures. Foot & Ankle International, 38, 921-929. https://doi.org/10.1177/1071100717709570
Lantto, I., Heikkinen, J., Flinkkilä, T., Ohtonen, P., & Leppilahti, J. (2015). Epidemiology of Achilles tendon ruptures: Increasing incidence over a 33-year period. Scandinavian Journal of Medicine & Science in Sports, 25, e133-e138. https://doi.org/10.1111/sms.12253
Lipar, M., Zdilar, B., Kreszinger, M., Ćorić, M., Radišić, B., Samardžija, M., … Pećin, M. (2018). Extracellular matrix supports healing of transected rabbit Achilles tendon. Heliyon, 4, e00781. https://doi.org/10.1016/j.heliyon.2018.e00781
Liu, Y., Peng, Y., Fang, Y., Yao, M., Redmond, R. W., & Ni, T. (2016). No midterm advantages in the middle term using small intestinal submucosa and human amniotic membrane in Achilles tendon transverse tenotomy. Journal of Orthopedic Surgical Research, 11, 125. https://doi.org/10.1186/s13018-016-0463-1
Meier Bürgisser, G., Calcagni, M., Müller, A., Bonavoglia, E., Fessel, G., Snedeker, J. G., … Buschmann, J. (2014). Prevention of peritendinous adhesions using an electrospun DegraPol polymer tube: A histological, ultrasonographic, and biomechanical study in rabbits. Biomedical Research International, 2014, 656240. https://doi.org/10.1155/2014/656240
Moshiri, A., Oryan, A., & Meimandi-Parizi, A. (2015). Synthesis, development, characterization and effectiveness of bovine pure platelet gel-collagen-polydioxanone bioactive graft on tendon healing. Journal of Cellular and Molecular Medicine, 19, 1308-1332. https://doi.org/10.1111/jcmm.12511
Moshiri, A., Oryan, A., Meimandi-Parizi, A., & Koohi-Hosseinabadi, O. (2014). Effectiveness of xenogenous-based bovine-derived platelet gel embedded within a three-dimensional collagen implant on the healing and regeneration of the Achilles tendon defect in rabbits. Expert Opinion on Biological Therapy, 14, 1065-1089. https://doi.org/10.1517/14712598.2014.915305
Moshiri, A., Oryan, A., Meimandi-Parizi, A., Silver, I. A., Tanideh, N., & Golestani, N. (2016). Effectiveness of hybridized nano- and microstructure biodegradable, biocompatible, collagen-based, three-dimensional bioimplants in repair of a large tendon-defect model in rabbits. Journal of Tissue Engineering and Regenerative Medicine, 10, 451-465. https://doi.org/10.1002/term.1740
Mueller, S. A., Durselen, L., Heisterbach, P., Evans, C., & Majewski, M. (2016). Effect of a simple collagen type I sponge for Achilles tendon repair in a rat model. The American Journal of Sports Medicine, 44, 1998-2004. https://doi.org/10.1177/0363546516641942
Najafbeygi, A., Fatemi, M. J., Lebaschi, A. H., Mousavi, S. J., Husseini, S. A., & Niazi, M. (2017). Effect of basic fibroblast growth factor on Achilles tendon healing in rabbit. World Journal of Plastic Surgery, 6, 26-32.
Oliva, F., Maffulli, N., Gissi, C., Veronesi, F., Calciano, L., Fini, M., … Berardi, A. C. (2019). Combined ascorbic acid and T3 produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: A proof of concept study. Journal of Orthopaedic Surgery and Research, 14, 54. https://doi.org/10.1186/s13018-019-1098-9
Oryan, A., Moshiri, A., Meimandi-Parizi, A., & Maffulli, N. (2015). Role of xenogenous bovine platelet gel embedded within collagen implant on tendon healing: An in vitro and in vivo study. Experimental Biology and Medicine, 240, 194-210. https://doi.org/10.1177/1535370214554532
Oryan, A., Sharifi, P., Moshiri, A., & Silver, I. A. (2017). The role of three-dimensional pure bovine gelatin scaffolds in tendon healing, modeling, and remodeling: An in vivo investigation with potential clinical value. Connecttive Tissue Research, 58, 424-437. https://doi.org/10.1080/03008207.2016.1238468
Pietschmann, M. F., Frankewycz, B., Schmitz, P., Docheva, D., Sievers, B., Jansson, V., … Müller, P. E. (2013). Comparison of tenocytes and mesenchymal stem cells seeded on biodegradable scaffolds in a full-size tendon defect model. Journal of Materials Science: Materials in Medicine, 24, 211-220. https://doi.org/10.1007/s10856-012-4791-3
Rieu, C., Picaut, L., Mosser, G., & Trichet, L. (2017). From tendon injury to collagen-based tendon regeneration: Overview and recent advances. Current Pharmaceutical Design, 23, 3483-3506. https://doi.org/10.2174/1381612823666170516130515
Riley, A., Isaacs, J. E., Cotterell, I., Stromberg, J., Mallu, S., & Patel, G. (2018). Tendon adhesions: A novel method of objectively measuring adhesions by assessing tendon glide through a soft tissue envelope in a rat model. The Journal of Hand Surgery, 43, 1134.e1-e6. https://doi.org/10.1016/j.jhsa.2018.02.033
Sandri, M., Filardo, G., Kon, E., Panseri, S., Montesi, M., Iafisco, M., … Tampieri, A. (2016). Fabrication and pilot in vivo study of a collagen-BDDGE-elastin core-shell scaffold for tendon regeneration. Frontiers in Bioengineering and Biotechnology, 4, 52. https://doi.org/10.3389/fbioe.2016.00052
Searle, S. R., Speed, F. M., & Milliken, G. A. (1980). Population marginal means in the linear model: An alternative to least squares means. American Statistical Association, 34, 216-221.
Selek, O., Buluc, L., Muezzinoglu, B., Ergün, R. E., Ayhan, S., & Karaöz, E. (2014). Mesenchymal stem cell application improves tendon healing via anti-apoptotic affect (animal study). Acta Orthopaedica et Traumatologica Turcica, 8, 187-195. https://doi.org/10.3944/AOTT.2014.2985
Shearn, J. T., Kinneberg, K. R., Dyment, N. A., Galloway, M. T., Kenter, K., Wylie, C., & Butler, D. L. (2011). Tendon tissue engineering: Progress, challenges, and translation to the clinic. Journal of Musculoskeletal and Neuronal Interactions, 11, 163-173.
Soslowsky, L. J., Carpenter, J. E., DeBano, C. M., Banerji, I., & Moalli, M. R. (1996). Development and use of an animal model for investigations on rotator cuff disease. Journal of Shoulder and Elbow Surgery, 5, 383-392. https://doi.org/10.1016/S1058-2746(96)80070-X
Sun, J., Mou, C., Shi, Q., Chen, B., Hou, X., Zhang, W., … Dai, J. (2018). Controlled release of collagen-binding SDF-1a from the collagen scaffold promoted tendon regeneration in a rat Achilles tendon defect model. Biomaterials, 162, 22-33. https://doi.org/10.1016/j.biomaterials.2018.02.008
Svensson, M., Kartus, J., Christensen, L. R., Movin, T., Papadogiannakis, N., & Karlsson, J. (2005). A long-term serial histological evaluation of the patellar tendon in humans after harvesting its central third. Knee Surgery, Sports Traumatology, Arthroscopy, 13, 398-404. https://doi.org/10.1007/s00167-004-0590-9
Tang, J. B. (2005). Clinical outcomes associated with flexor tendon repair. Hand Clinics, 21, 199-210. https://doi.org/10.1016/j.hcl.2004.11.005
Tang, K. L., Thermann, H., Dai, G., Chen, G. X., Guo, L., & Yang, L. (2007). Arthroscopically assisted percutaneous repair of fresh closed Achilles tendon rupture by Kessler's suture. The American Journal of Sports Medicine, 35, 589-596. https://doi.org/10.1177/0363546506295080
Tang, L., Yang, Y., Li, Y., Yang, G., Luo, T., Xu, Y., & Zhang, W. (2018). Knitted silk mesh-like scaffold incorporated with sponge-like regenerated silk fibroin/collagen I and seeded with mesenchymal stem cells for repairing Achilles tendon in rabbits. Acta of Bioengineering and Biomechanics, 20, 77-87.
Tang, Y., Leng, Q., Xiang, X., Zhang, L., Yang, Y., & Qiu, L. (2015). Use of ultrasound-targeted microbubble destruction to transfect IGF-1 cDNA to enhance the regeneration of rat wounded Achilles tendon in vivo. Gene Therapy, 22, 610-618. https://doi.org/10.1038/gt.2015.32
Tosun, H. B., Gümüştaş, S. A., Kom, M., Uludağ, A., Serbest, S., & Eröksüz, Y. (2016). The effect of sodium hyaluronate plus sodium chondroitin sulfate solution on peritendinous adhesion and tendon healing: An experimental study. Balkan Medical Journal, 33, 258-266. https://doi.org/10.5152/balkanmedj.2016.140172
Van Kampen, C., Arnoczky, S., Parks, P., Hackett, E., Ruehlman, D., Turner, A., & Schlegel, T. (2013). Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: A histological evaluation in sheep. Muscle, Ligaments and Tendons Journal, 3, 229-235.
Veronesi, F., Torricelli, P., Della Bella, E., Pagani, S., & Fini, M. (2015). In vitro mutual interaction between tenocytes and adipose-derived mesenchymal stromal cells. Cytotherapy, 17, 215-223. https://doi.org/10.1016/j.jcyt.2014.10.006
Wichelhaus, D. A., Beyersdoerfer, S. T., Gierer, P., Vollmar, B., & Mittlmeier, T. (2016). The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model. Archives of Orthopaedic and Trauma Surgery, 136, 1021-1029. https://doi.org/10.1007/s00402-016-2472-2
Xiang, X., Leng, Q., Tang, Y., Wang, L., Huang, J., Zhang, Y., & Qiu, L. (2018). Ultrasound-targeted microbubble destruction delivery of insulin-like growth factor 1 cDNA and transforming growth factor beta short hairpin RNA enhances tendon regeneration and inhibits scar formation in vivo. Human Gene Therapy. Clinical Development, 29, 198-213. https://doi.org/10.1089/humc.2018.121
Yang, Z., Cao, H., Gao, S., Yang, M., Lyu, J., & Tang, K. (2017). Effect of tendon stem cells in chitosan/β-glycerophosphate/collagen hydrogel on Achilles tendon healing in a rat model. Medical Science Monitor, 23, 4633-4643. https://doi.org/10.12659/MSM.906747
Zhang, W., Li, X., Comes Franchini, M., Xu, K., Locatelli, E., Martin, R. C., … Cui, S. (2016). Controlled release of curcumin from curcumin-loaded nanomicelles to prevent peritendinous adhesion during Achilles tendon healing in rats. International Journal of Nanomedicine, 11, 2873-2881. https://doi.org/10.2147/IJN.S103867
Zhang, W., Yang, Y., Zhang, K., Li, Y., & Fang, G. (2015). Weft-knitted silk-poly(lactide-co-glycolide) mesh scaffold combined with collagen matrix and seeded with mesenchymal stem cells for rabbit Achilles tendon repair. Connective Tissue Research, 56, 25-34. https://doi.org/10.3109/03008207.2014.976309
Zhao, H., Guan, H. G., Gu, J., Luo, Z. P., Zhang, W., Chen, B., … Shi, Q. (2013). Collagen membrane alleviates peritendinous adhesion in the rat Achilles tendon injury model. Chinese Medical Journal, 126, 729-733.