Influence of chronic hyperoxia on the developmental time course of the hypoxic ventilatory response relative to other traits in rats.
Biphasic hypoxic ventilatory response
Control of breathing
Heterokairy
Metabolic rate
Postnatal development
Thermogenesis
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
06
04
2020
revised:
03
06
2020
accepted:
22
06
2020
pubmed:
1
7
2020
medline:
6
10
2021
entrez:
29
6
2020
Statut:
ppublish
Résumé
Newborn mammals exhibit a biphasic hypoxic ventilatory response (HVR) in which an initial increase in ventilation is followed by a decline back toward baseline levels. The magnitude of the secondary decline diminishes with postnatal age, but this transition occurs earlier in rat pups reared in moderate hyperoxia. This pattern is consistent with heterokairy, a form of developmental plasticity in which environmental factors alter the timing of developmental events. The present study investigated whether this plasticity is specific to the HVR or if hyperoxia instead accelerates overall development. Rat pups reared in 60 % O
Identifiants
pubmed: 32593590
pii: S1569-9048(20)30141-5
doi: 10.1016/j.resp.2020.103483
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103483Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.