Psychological distress in cervical cancer screening: results from a German online survey.


Journal

Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213

Informations de publication

Date de publication:
09 2020
Historique:
received: 11 04 2020
accepted: 18 06 2020
pubmed: 1 7 2020
medline: 28 10 2020
entrez: 29 6 2020
Statut: ppublish

Résumé

The PODCAD study aimed at assessing the degree of psychological stress that women experience due to notification of an abnormal Papanicolaou (Pap) smear finding or a positive human papillomavirus (HPV) test result. We designed a survey to address the question of psychological burden due to abnormal Pap smear results and/or positive HPV tests. In this online campaign approach, we aimed to reach > 2000 women all over Germany irrespective of kind and number of abnormal screening findings. We asked for different kinds of anxiety, distress and uncertainty regarding both, Pap and HPV status. A total of 3753 women completed the survey at least partially, and almost 2300 fully completed the survey. Of these, more than 50% were affected already since more than 1 year, and almost half of them had experienced at least three Pap smears in follow-up examinations. Almost 70% of the women were afraid of developing cancer. Intriguingly, almost half of the women with abnormal findings were not aware of their stage of the Pap smear. Furthermore, almost 30% of the women displayed signs of a post-traumatic stress disorder. Abnormal results in cervical cancer screening have an impact on patients' psychology, irrespective of the knowledge and severity of the findings. Better information concerning risks and benefits of cervical cancer screening and about the meaning of the outcome of its procedures are required to decrease this anxiety.

Identifiants

pubmed: 32594298
doi: 10.1007/s00404-020-05661-9
pii: 10.1007/s00404-020-05661-9
pmc: PMC7447652
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

699-705

Références

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
doi: 10.3322/caac.21492
Cuzick J, Clavel C, Petry KU, Meijer CJ, Hoyer H, Ratnam S, Szarewski A, Birembaut P, Kulasingam S, Sasieni P, Iftner T (2006) Overview of the European and North American studies on HPV testing in primary cervical cancer screening. Int J Cancer 119(5):1095–1101
doi: 10.1002/ijc.21955
Rijkaart DC, Berkhof J, Rozendaal L, van Kemenade FJ, Bulkmans NWJ, Heideman DAM, Kenter GG, Cuzick J, Snijders PJF, Meijer CJLM (2012) Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial. Lancet Oncol 13(1):78–88
doi: 10.1016/S1470-2045(11)70296-0
Wright TC, Stoler MH, Behrens CM, Sharma A, Zhang G, Wright TL (2015) Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test. Gynecol Oncol 136(2):189–197
doi: 10.1016/j.ygyno.2014.11.076
Hillemanns P, Friese K, Dannecker C, Klug S, Seifert U, Iftner T, Hadicke J, Loning T, Horn L, Schmidt D, Ikenberg H, Steiner M, Freitag U, Siebert U, Sroczynski G, Sauerbrei W, Beckmann MW, Gebhardt M, Friedrich M, Munstedt K, Schneider A, Kaufmann A, Petry KU, Schafer APA, Pawlita M, Weis J, Mehnert A, Fehr M, Grimm C, Reich O, Arbyn M, Kleijnen J, Wesselmann S, Nothacker M, Follmann M, Langer T, Jentschke M (2019) Prevention of Cervical Cancer: guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017)—Part 1 with introduction, screening and the pathology of cervical dysplasia. Geburtshilfe Frauenheilkd 79(2):148–159
doi: 10.1055/a-0818-5440
Myers ER, McCrory DC, Nanda K, Bastian L, Matchar DB (2000) Mathematical model for the natural history of human papillomavirus infection and cervical carcinogenesis. Am J Epidemiol 151(12):1158–1171
doi: 10.1093/oxfordjournals.aje.a010166
Blomberg K, Tishelman C, Ternestedt BM, Tornberg S, Leval A, Widmark C (2011) How can young women be encouraged to attend cervical cancer screening? Suggestions from face-to-face and internet focus group discussions with 30-year-old women in Stockholm, Sweden. Acta Oncol (Stockholm, Sweden) 50(1):112–120
doi: 10.3109/0284186X.2010.528790
Hellsten C, Lindqvist PG, Sjostrom K (2008) A longitudinal study of sexual functioning in women referred for colposcopy: a 2-year follow up. BJOG 115(2):205–211
doi: 10.1111/j.1471-0528.2007.01503.x
Hellsten C, Sjostrom K, Lindqvist PG (2009) A longitudinal 2-year follow-up of quality of life in women referred for colposcopy after an abnormal cervical smear. Eur J Obstet Gynecol Reprod Biol 147(2):221–225
doi: 10.1016/j.ejogrb.2009.09.002
Heinonen A, Tapper AM, Leminen A, Sintonen H, Roine RP (2013) Health-related quality of life and perception of anxiety in women with abnormal cervical cytology referred for colposcopy: an observational study. Eur J Obstet Gynecol Reprod Biol 169(2):387–391
doi: 10.1016/j.ejogrb.2013.03.033
Rask M, Swahnberg K, Lindell G, Oscarsson M (2017) Women’s experiences of abnormal Pap smear results—a qualitative study. Sex Reprod Healthc 12:3–8
doi: 10.1016/j.srhc.2017.01.002
Rask M, Oscarsson M, Lindell G, Swahnberg K (2016) Women with abnormal Pap smear result: a qualitative study of Swedish healthcare professionals’ experiences. Eur J Cancer Care (Engl) 25(6):980–991
doi: 10.1111/ecc.12415
Oscarsson MG (2011) Psychological adjustment of women in cervical cancer screening. Curr Women Health Revi. 7(4):353–357
doi: 10.2174/157340411799079607
Thangarajah F, Einzmann T, Bergauer F, Patzke J, Schmidt-Petruschkat S, Theune M, Engel K, Puppe J, Richters L, Mallmann P, Kirn V (2016) Cervical screening program and the psychological impact of an abnormal Pap smear: a self-assessment questionnaire study of 590 patients. Arch Gynecol Obstet 293(2):391–398
doi: 10.1007/s00404-015-3821-z
Korfage IJ, Essink-Bot ML, Westenberg SM, Helmerhorst T, Habbema JD, van Ballegooijen M (2014) How distressing is referral to colposcopy in cervical cancer screening?: a prospective quality of life study. Gynecol Oncol 132(1):142–148
doi: 10.1016/j.ygyno.2013.11.001
Rask M, Oscarsson M, Ludwig N, Swahnberg K (2017) The Swedish translation and cross-cultural adaptation of the functional assessment of chronic illness therapy—cervical dysplasia (FACIT-CD): linguistic validity and reliability of the Swedish version. BMC Womens Health 17(1):24
doi: 10.1186/s12905-017-0381-3
Rask M, Swahnberg K, Oscarsson M (2019) Notification of an abnormal Pap smear result: an intervention study. Eur J Cancer Care (Engl) 28(2):e12969
doi: 10.1111/ecc.12969
Rothnie K, Cotton SC, Fielding S, Gray NM, Little J, Cruickshank ME, Walker LG, Avis M, Sharp L (2014) Measuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM). Health Qual Life Outcomes 12:154
doi: 10.1186/s12955-014-0154-8
Shinn E, Basen-Engquist K, Le T, Hansis-Diarte A, Bostic D, Martinez-Cross J, Santos A, Follen M (2004) Distress after an abnormal Pap smear result: scale development and psychometric validation. Prev Med 39(2):404–412
doi: 10.1016/j.ypmed.2004.02.004
Nagele E, Reich O, Greimel E, Dorfer M, Haas J, Trutnovsky G (2016) Sexual activity, psychosexual distress, and fear of progression in women with human papillomavirus-related premalignant genital lesions. J Sex Med 13(2):253–259
doi: 10.1016/j.jsxm.2015.12.012
O’Connor M, Gallagher P, Waller J, Martin CM, O’Leary JJ, Sharp L (2015) Adverse psychological outcomes following colposcopy and related procedures: a systematic review. BJOG 123(1):24–38
doi: 10.1111/1471-0528.13462
Balasubramani L, Orbell S, Hagger M, Brown V, Tidy J (2007) Do women with high-grade cervical intraepithelial neoplasia prefer a see and treat option in colposcopy? BJOG 114(1):39–45
doi: 10.1111/j.1471-0528.2006.01160.x
Ilic I, Babic G, Dimitrijevic A, Ilic M, SipeticGrujicic S (2019) Psychological distress among women with abnormal pap smear results in Serbia: validity and reliability of the Cervical Dysplasia Distress Questionnaire. PLoS ONE. 14(6):e0218070
doi: 10.1371/journal.pone.0218070
Frederiksen ME, Njor S, Lynge E, Rebolj M (2015) Psychological effects of diagnosis and treatment of cervical intraepithelial neoplasia: a systematic review. Sex Transm Infect 91(4):248–256
doi: 10.1136/sextrans-2014-051754
Gemeinsamer Bundesausschuss. Richtlinie des Gemeinsamen Bundesausschusses für organisierte Krebsfrüherkennungsprogramme—oKFE-Richtlinie/oKFE-RL. 2019. https://www.g-ba.de/downloads/62-492-1844/oKFE-RL-2018-11-22-iK-2019-07-01_WZ.pdf . Accessed 15 Dec 2019.
Kessler RC (2000) Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry. 61(5):4–12
pubmed: 10761674
Sareen J, Cox BJ, Stein MB, Afifi TO, Fleet C, Asmundson GJ (2007) Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosom Med 69(3):242–248
doi: 10.1097/PSY.0b013e31803146d8
Palmer AG, Tucker S, Warren R, Adams M (1993) Understanding women’s responses to treatment for cervical intra-epithelial neoplasia. Br J Clin Psychol 32(1):101–112
doi: 10.1111/j.2044-8260.1993.tb01033.x
Freeman-Wang T, Walker P, Linehan J, Coffey C, Glasser B, Sherr L (2001) Anxiety levels in women attending colposcopy clinics for treatment for cervical intraepithelial neoplasia: a randomised trial of written and video information. BJOG 108(5):482–484
pubmed: 11368133
de Bie RP, Massuger LF, Lenselink CH, Derksen YH, Prins JB, Bekkers RL (2011) The role of individually targeted information to reduce anxiety before colposcopy: a randomised controlled trial. BJOG 118(8):945–950
doi: 10.1111/j.1471-0528.2011.02996.x
Kitchener HC, Fletcher I, Roberts C, Wheeler P, Almonte M, Maguire P (2008) The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial. Int J Gynecol Cancer 18(4):743–748
doi: 10.1111/j.1525-1438.2007.01113.x

Auteurs

M Jentschke (M)

Department of Gynaecology and Obstetrics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Jentschke.Matthias@mh-hannover.de.

R Lehmann (R)

DontBePatient Intelligence GmbH, c/o GCI Management, Brienner Str. 7, 80333, Munich, Germany.

N Drews (N)

DontBePatient Intelligence GmbH, c/o GCI Management, Brienner Str. 7, 80333, Munich, Germany.

A Hansel (A)

Oncgnostics GmbH, Winzerlaer Str. 2, 07745, Jena, Germany.

M Schmitz (M)

Oncgnostics GmbH, Winzerlaer Str. 2, 07745, Jena, Germany.

P Hillemanns (P)

Department of Gynaecology and Obstetrics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH