Mindfulness, Education, and Exercise for age-related cognitive decline: Study protocol, pilot study results, and description of the baseline sample.
Meditation
aerobic exercise
aging
elderly
intervention study
Journal
Clinical trials (London, England)
ISSN: 1740-7753
Titre abrégé: Clin Trials
Pays: England
ID NLM: 101197451
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
1
7
2020
medline:
14
1
2021
entrez:
30
6
2020
Statut:
ppublish
Résumé
Age-related cognitive decline is a pervasive problem in our aging population. To date, no pharmacological treatments to halt or reverse cognitive decline are available. Behavioral interventions, such as physical exercise and Mindfulness-Based Stress Reduction, may reduce or reverse cognitive decline, but rigorously designed randomized controlled trials are needed to test the efficacy of such interventions. Here, we describe the design of the Mindfulness, Education, and Exercise study, an 18-month randomized controlled trial that will assess the effect of two interventions-mindfulness training plus moderate-to-vigorous intensity exercise or moderate-to-vigorous intensity exercise alone-compared with a health education control group on cognitive function in older adults. An extensive battery of biobehavioral assessments will be used to understand the mechanisms of cognitive remediation, by using structural and resting state functional magnetic resonance imaging, insulin sensitivity, inflammation, and metabolic and behavioral assessments. We provide the results from a preliminary study (n = 29) of non-randomized pilot participants who received both the exercise and Mindfulness-Based Stress Reduction interventions. We also provide details on the recruitment and baseline characteristics of the randomized controlled trial sample (n = 585). When complete, the Mindfulness, Education, and Exercise study will inform the research community on the efficacy of these widely available interventions improve cognitive functioning in older adults.
Sections du résumé
BACKGROUND/AIMS
Age-related cognitive decline is a pervasive problem in our aging population. To date, no pharmacological treatments to halt or reverse cognitive decline are available. Behavioral interventions, such as physical exercise and Mindfulness-Based Stress Reduction, may reduce or reverse cognitive decline, but rigorously designed randomized controlled trials are needed to test the efficacy of such interventions.
METHODS
Here, we describe the design of the Mindfulness, Education, and Exercise study, an 18-month randomized controlled trial that will assess the effect of two interventions-mindfulness training plus moderate-to-vigorous intensity exercise or moderate-to-vigorous intensity exercise alone-compared with a health education control group on cognitive function in older adults. An extensive battery of biobehavioral assessments will be used to understand the mechanisms of cognitive remediation, by using structural and resting state functional magnetic resonance imaging, insulin sensitivity, inflammation, and metabolic and behavioral assessments.
RESULTS
We provide the results from a preliminary study (n = 29) of non-randomized pilot participants who received both the exercise and Mindfulness-Based Stress Reduction interventions. We also provide details on the recruitment and baseline characteristics of the randomized controlled trial sample (n = 585).
CONCLUSION
When complete, the Mindfulness, Education, and Exercise study will inform the research community on the efficacy of these widely available interventions improve cognitive functioning in older adults.
Identifiants
pubmed: 32594789
doi: 10.1177/1740774520931864
pmc: PMC7529857
mid: NIHMS1594756
doi:
Types de publication
Clinical Trial Protocol
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
581-594Subventions
Organisme : NIA NIH HHS
ID : R01 AG049369
Pays : United States
Références
Sleep Health. 2018 Apr;4(2):209-216
pubmed: 29555136
Med Sci Sports Exerc. 2008 Jan;40(1):181-8
pubmed: 18091006
J Biomech. 2016 Dec 8;49(16):4142-4145
pubmed: 27789036
J Sports Sci. 2012;30(13):1429-35
pubmed: 22857599
Dialogues Clin Neurosci. 2013 Mar;15(1):99-108
pubmed: 23576893
Br J Sports Med. 2014 Jul;48(13):1019-23
pubmed: 24782483
Diabetes Care. 1999 Sep;22(9):1462-70
pubmed: 10480510
Neuroscience. 2004;124(1):71-9
pubmed: 14960340
J Alzheimers Dis. 2018;62(2):579-581
pubmed: 29480202
Trends Cogn Sci. 2013 Oct;17(10):525-44
pubmed: 24029446
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15649-52
pubmed: 20713717
J Clin Psychol. 2008 Jul;64(7):840-62
pubmed: 18484600
Neuropsychologia. 2012 Feb;50(3):357-66
pubmed: 22172547
Psychoneuroendocrinology. 2004 May;29(4):448-74
pubmed: 14749092
J Neurochem. 2019 Jun;149(5):562-581
pubmed: 30702751
Neurology. 2009 Jun 9;72(23):2029-35
pubmed: 19506226
Soc Cogn Affect Neurosci. 2007 Dec;2(4):313-22
pubmed: 18985137
J Sleep Res. 2012 Aug;21(4):390-5
pubmed: 22098127
Psychosom Med. 2013 Oct;75(8):721-8
pubmed: 24127622
Brain Behav Immun. 2007 Nov;21(8):1038-49
pubmed: 17521871
Am J Psychiatry. 1992 Jul;149(7):936-43
pubmed: 1609875
Obesity (Silver Spring). 2006 Mar;14(3):345-56
pubmed: 16648603
Explore (NY). 2009 Sep-Oct;5(5):265-71
pubmed: 19733812
Neuroscience. 2008 Sep 9;155(4):1048-58
pubmed: 18664375
Psychosomatics. 2013 Mar-Apr;54(2):158-64
pubmed: 23218058
Compr Physiol. 2013 Jan;3(1):403-28
pubmed: 23720292
Diabetologia. 2003 Jul;46(7):1007-12
pubmed: 12827244
Complement Ther Clin Pract. 2011 May;17(2):65-70
pubmed: 21457893
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2367-72
pubmed: 20133882
Eur J Cardiovasc Prev Rehabil. 2010 Apr;17(2):127-39
pubmed: 20215971
J Consult Clin Psychol. 2016 Apr;84(4):345-52
pubmed: 26881447
Exp Neurol. 2019 Mar;313:79-87
pubmed: 30576640
Transl Psychiatry. 2017 Jun 6;7(6):e1148
pubmed: 28585932
Gen Hosp Psychiatry. 1995 May;17(3):192-200
pubmed: 7649463
J Ment Health Policy Econ. 2011 Dec;14(4):201-8
pubmed: 22345362
Neurology. 2010 Oct 19;75(16):1415-22
pubmed: 20944075
Front Aging Neurosci. 2019 Mar 01;11:43
pubmed: 30881301
J Nutr Health Aging. 2012 Apr;16(4):331-5
pubmed: 22499452
J Int Neuropsychol Soc. 2014 Jul;20(6):611-9
pubmed: 24960230
Neurology. 2013 Mar 12;80(11 Suppl 3):S54-64
pubmed: 23479546
J Gerontol. 1994 Mar;49(2):M85-94
pubmed: 8126356
Hum Brain Mapp. 2017 Nov;38(11):5666-5680
pubmed: 28782901
Emotion. 2010 Feb;10(1):83-91
pubmed: 20141305
Psychol Rep. 2019 Apr;122(2):465-484
pubmed: 29368545
Curr Top Behav Neurosci. 2013;15:189-210
pubmed: 22847651
Psychol Aging. 2010 Mar;25(1):208-18
pubmed: 20230140
Neuroimage. 2014 Jan 1;84:320-41
pubmed: 23994314
Neuropsychology. 2013 Sep;27(5):516-28
pubmed: 24040929
Ageing Res Rev. 2019 Jul;52:72-119
pubmed: 31059801
J Holist Nurs. 2012 Sep;30(3):170-85
pubmed: 22442202
Neuropsychobiology. 2012;65(3):109-18
pubmed: 22377965
Psychol Methods. 2009 Sep;14(3):202-24
pubmed: 19719358
J Clin Psychiatry. 2017 Jul;78(7):e734-e743
pubmed: 28686822
Int J Geriatr Psychiatry. 2014 Oct;29(10):991-1000
pubmed: 24677282
Sleep. 1994 Apr;17(3):201-7
pubmed: 7939118
Methods Mol Biol. 2019;2020:91-114
pubmed: 31177494
Psychiatry Res. 2011 Jan 30;191(1):36-43
pubmed: 21071182
Yale J Biol Med. 2013 Mar;86(1):41-7
pubmed: 23482244
Neurosci Lett. 2013 Nov 27;556:15-9
pubmed: 24120430
Mindfulness (N Y). 2017;8(1):204-217
pubmed: 28163797
Ann N Y Acad Sci. 2016 Jun;1373(1):13-24
pubmed: 26799456
Ann Behav Med. 2007 Feb;33(1):11-21
pubmed: 17291166
J Cogn Neurosci. 2017 Nov;29(11):1895-1907
pubmed: 28699808
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10570-4
pubmed: 22689998
Med Sci Sports Exerc. 2015 Apr;47(4):833-8
pubmed: 25102292
J Neurosci. 2009 Oct 21;29(42):13418-27
pubmed: 19846729
Behav Ther. 2017 Jul;48(4):567-580
pubmed: 28577591
Sleep. 1992 Oct;15(5):461-9
pubmed: 1455130
J Appl Gerontol. 2005;24(3):211-230
pubmed: 18160968
Sleep Med Clin. 2018 Mar;13(1):93-106
pubmed: 29412987
Age Ageing. 2014 Sep;43(5):623-9
pubmed: 24554791
J Community Health. 2000 Aug;25(4):279-92
pubmed: 10941692
Diabetes Care. 2001 Mar;24(3):539-48
pubmed: 11289482
J Neurosci. 2005 Sep 21;25(38):8680-5
pubmed: 16177036
Curr Oncol. 2010 Aug;17(4):62-70
pubmed: 20697517
J Holist Nurs. 2011 Jun;29(2):107-17
pubmed: 21041554
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Gerontologist. 2019 Nov 16;59(6):e782-e790
pubmed: 30796782
Med Sci Sports Exerc. 2012 Jan;44(1 Suppl 1):S1-4
pubmed: 22157769
Int J Behav Nutr Phys Act. 2015 Feb 11;12:11
pubmed: 25881074
Health Psychol. 2013 Oct;32(10):1110-3
pubmed: 23527521
Neuron. 2007 Dec 6;56(5):924-35
pubmed: 18054866
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573
Med Sci Sports Exerc. 2012 Jan;44(1 Suppl 1):S86-9
pubmed: 22157779
BMJ. 2015 May 08;350:h2147
pubmed: 25956159