Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort.
Direct-acting antivirals
Hepatitis C virus
Hepatocellular carcinoma recurrence
Tumor growth
Journal
Clinics and research in hepatology and gastroenterology
ISSN: 2210-741X
Titre abrégé: Clin Res Hepatol Gastroenterol
Pays: France
ID NLM: 101553659
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
01
2020
revised:
08
04
2020
accepted:
23
04
2020
pubmed:
1
7
2020
medline:
24
12
2021
entrez:
30
6
2020
Statut:
ppublish
Résumé
Although it has now been excluded that direct-acting antivirals (DAA) are associated with a significant risk of hepatocellular carcinoma (HCC) in HCV-infected patients, a possible effect of DAA on tumor growth is still a subject of debate. We performed a blind comparison of the kinetics of HCC recurrence in patients after HCV treatment with or without DAA to evaluate the potential aggressiveness of HCC after DAA treatment. Thirty-nine HCV-infected patients from the AFEF/ANRS CO22 Hepather cohort who experienced HCC recurrence after so-called curative treatment were evaluated. Contrast-enhanced CT and/or MR images were read blindly 6 months before HCC recurrence and during the follow-up period. Seventeen patients who received DAA (DAA+) before HCC recurrence were compared to the 22 who did not receive (DAA-), according to the LiRads and mRECIST criteria. There were 28 men and 11 women, median age 62 years old, 37 (95%) with cirrhosis. DAA+ patients had a lower median MELD score (8±2 vs. 10±4, P=0.0286) than DAA- patients. The median time to HCC recurrence (time from the date of curative treatment to the diagnosis of recurrence) was not different (20 vs. 18 months) (P=0.73) between the two groups. There was no difference between the 2 groups in the overall survival and/or transplantation-free survival (P=0.71) and for the mRECIST time to progression (P=0.25). This blinded analysis of HCC recurrence after HCC treatment does not support any negative impact of DAA therapy on the severity or progression of recurrent HCC.
Sections du résumé
BACKGROUND
BACKGROUND
Although it has now been excluded that direct-acting antivirals (DAA) are associated with a significant risk of hepatocellular carcinoma (HCC) in HCV-infected patients, a possible effect of DAA on tumor growth is still a subject of debate. We performed a blind comparison of the kinetics of HCC recurrence in patients after HCV treatment with or without DAA to evaluate the potential aggressiveness of HCC after DAA treatment.
BASIC PROCEDURES
METHODS
Thirty-nine HCV-infected patients from the AFEF/ANRS CO22 Hepather cohort who experienced HCC recurrence after so-called curative treatment were evaluated. Contrast-enhanced CT and/or MR images were read blindly 6 months before HCC recurrence and during the follow-up period. Seventeen patients who received DAA (DAA+) before HCC recurrence were compared to the 22 who did not receive (DAA-), according to the LiRads and mRECIST criteria.
MAIN FINDINGS
RESULTS
There were 28 men and 11 women, median age 62 years old, 37 (95%) with cirrhosis. DAA+ patients had a lower median MELD score (8±2 vs. 10±4, P=0.0286) than DAA- patients. The median time to HCC recurrence (time from the date of curative treatment to the diagnosis of recurrence) was not different (20 vs. 18 months) (P=0.73) between the two groups. There was no difference between the 2 groups in the overall survival and/or transplantation-free survival (P=0.71) and for the mRECIST time to progression (P=0.25).
CONCLUSION
CONCLUSIONS
This blinded analysis of HCC recurrence after HCC treatment does not support any negative impact of DAA therapy on the severity or progression of recurrent HCC.
Identifiants
pubmed: 32595103
pii: S2210-7401(20)30152-2
doi: 10.1016/j.clinre.2020.04.022
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101459Investigateurs
Delphine Bonnet
(D)
Virginie Payssan-Sicart
(V)
Chloe Pomes
(C)
François Bailly
(F)
Marjolaine Beaudoin
(M)
Dominique Giboz
(D)
Kerstin Hartig-Lavie
(K)
Marianne Maynard
(M)
Eric Billaud
(E)
David Boutoille
(D)
Morane Cavellec
(M)
Marjorie Cheraud-Carpentier
(M)
Isabelle Hubert
(I)
Jaouad Benhida
(J)
Adrien Lannes
(A)
Françoise Lunel
(F)
Frédéric Oberti
(F)
Nathalie Boyer
(N)
Nathalie Giuily
(N)
Corinne Castelnau
(C)
Giovanna Scoazec
(G)
Aziza Chibah
(A)
Sylvie Keser
(S)
Karim Bonardi
(K)
Anaïs Vallet-Pichard
(A)
Philippe Sogni
(P)
Juliette Foucher
(J)
Jean-Baptiste Hiriart
(JB)
Amy Wilson
(A)
Sarah Shili
(S)
Faiza Chermak
(F)
Christelle Ansaldi
(C)
Nisserine Ben Amara
(NB)
Laëtitia Chouquet
(L)
Emilie De Luca
(E)
Valérie Oules
(V)
Rodolphe Anty
(R)
Eve Gelsi
(E)
Régine Truchi
(R)
Elena Luckina
(E)
Nadia Messaoudi
(N)
Joseph Moussali
(J)
Barbara De Dieuleveult
(B)
Damien Labarriere
(D)
Pascal Poter
(P)
Si Nafa Si Ahmed
(SNS)
Véronique Grando-Lemaire
(V)
Pierre Nahon
(P)
Valérie Bourcier
(V)
Séverine Brulé
(S)
Thomas Stalhberger
(T)
Caroline Jezequel
(C)
Audrey Brener
(A)
Anne Laligant
(A)
Aline Rabot
(A)
Isabelle Renard
(I)
Thomas F Baumert
(TF)
Michel Dofföel
(M)
Catherine Mutter
(C)
Pauline Simo-Noumbissie
(P)
Esma Razi
(E)
Hélène Barraud
(H)
Mouni Bensenane
(M)
Abdelbasset Nani
(A)
Sarah Hassani-Nani
(S)
Marie-Albertine Bernard
(MA)
Georges-Philippe Pageaux
(GP)
Michael Bismuth
(M)
Ludovic Caillo
(L)
Stéphanie Faure
(S)
Marie-Pierre Ripault
(MP)
Christophe Bureau
(C)
Jean Marie Peron
(JM)
Marie-Angèle Robic
(MA)
Léa Tarallo
(L)
Marine Faure
(M)
Bruno Froissart
(B)
Marie-Noelle Hilleret
(MN)
Jean-Pierre Zarski
(JP)
Odile Goria
(O)
Victorien Grard
(V)
Hélène Montialoux
(H)
Muriel François
(M)
Christian Ouedraogo
(C)
Christelle Pauleau
(C)
Anne Varault
(A)
Tony Andreani
(T)
Bénédicte Angoulevant
(B)
Azeline Chevance
(A)
Lawrence Serfaty
(L)
Teresa Antonini
(T)
Audrey Coilly
(A)
Jean-Charles Duclos Vallée
(JD)
Mariagrazia Tateo
(M)
Corinne Bonny
(C)
Chanteranne Brigitte
(C)
Géraldine Lamblin
(G)
Léon Muti
(L)
Abdenour Babouri
(A)
Virginie Filipe
(V)
Abdenour Babouri
(A)
Virginie Filipe
(V)
Camille Barrault
(C)
Laurent Costes
(L)
Hervé Hagège
(H)
Soraya Merbah
(S)
Paul Carrier
(P)
Maryline Debette-Gratien
(M)
Jérémie Jacques
(J)
Guillaume Lassailly
(G)
Florent Artu
(F)
Valérie Canva
(V)
Sébastien Dharancy
(S)
Alexandre Louvet
(A)
Marianne Latournerie
(M)
Marc Bardou
(M)
Thomas Mouillot
(T)
Yannick Bacq
(Y)
Didier Barbereau
(D)
Charlotte Nicolas
(C)
Caroline Chevalier
(C)
Isabelle Archambeaud
(I)
Sarah Habes
(S)
Nisserine Ben Amara
(NB)
Danièle Botta-Fridlund
(D)
Eric Saillard
(E)
Marie-Josée Lafrance
(MJ)
Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.