Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review.
antifungal drug
oral fluid
population pharmacokinetic model
precision dosing
saliva
therapeutic drug monitoring
voriconazole
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
12
2019
accepted:
01
06
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
1
7
2020
Statut:
epublish
Résumé
Precision dosing for many antifungal drugs is now recommended. Saliva sampling is considered as a non-invasive alternative to plasma sampling for therapeutic drug monitoring (TDM). However, there are currently no clinically validated saliva models available. The aim of this study is firstly, to conduct a systematic review to evaluate the evidence supporting saliva-based TDM for azoles, echinocandins, amphotericin B, and flucytosine. The second aim is to develop a saliva population pharmacokinetic (PK) model for eligible drugs, based on the evidence. Databases were searched up to July 2019 on PubMed
Identifiants
pubmed: 32595511
doi: 10.3389/fphar.2020.00894
pmc: PMC7304296
doi:
Types de publication
Journal Article
Langues
eng
Pagination
894Informations de copyright
Copyright © 2020 Kim, Märtson, Dreesen, Spriet, Wicha, McLachlan and Alffenaar.
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