Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation.
A1-R
CD73
adenosine
arrhythmias
hypoxia
translational models
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
01
2020
accepted:
23
04
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
1
7
2020
Statut:
epublish
Résumé
Adenosine leads to atrial action potential (AP) shortening through activation of adenosine 1 receptors (A The aim of this study was to address whether the pharmacological blockade of endogenous production of adenosine and of its signaling prevents atrial fibrillation (AF). The role of A As expected, CCPA shortened AP duration at 90% of repolarization (APD A
Sections du résumé
BACKGROUND
BACKGROUND
Adenosine leads to atrial action potential (AP) shortening through activation of adenosine 1 receptors (A
OBJECTIVE
OBJECTIVE
The aim of this study was to address whether the pharmacological blockade of endogenous production of adenosine and of its signaling prevents atrial fibrillation (AF).
METHODS
METHODS
The role of A
RESULTS
RESULTS
As expected, CCPA shortened AP duration at 90% of repolarization (APD
CONCLUSION
CONCLUSIONS
A
Identifiants
pubmed: 32595514
doi: 10.3389/fphys.2020.00493
pmc: PMC7304385
doi:
Types de publication
Journal Article
Langues
eng
Pagination
493Informations de copyright
Copyright © 2020 Soattin, Lubberding, Bentzen, Christ and Jespersen.
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