Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option?
epilepsy
genetic epilepsies
status epilepticus
treatment
vagal nerve stimulation (VNS)
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
01
2020
accepted:
27
04
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
1
7
2020
Statut:
epublish
Résumé
Refractory and super-refractory status epilepticus (RSE, SRSE) are severe conditions that can have long-term neurological consequences with high morbidity and mortality rates. The usefulness of vagus nerve-stimulation (VNS) implantation during RSE has been documented by anecdotal cases and in systematic reviews; however, the use of VNS in RSE has not been widely adopted. We successfully implanted VNS in two patients with genetic epilepsy admitted to hospital for SRSE; detailed descriptions of the clinical findings and VNS parameters are provided. Our patients were implanted 25 and 58 days after status epilepticus (SE) onset, and a stable remission of SE was observed from the seventh and tenth day after VNS implantation, respectively, without change in anti-seizure medication. We used a fast ramp-up of stimulation without evident side effects. Our results support the consideration of VNS implantation as a safe and effective adjunctive treatment for SRSE.
Identifiants
pubmed: 32595584
doi: 10.3389/fneur.2020.00443
pmc: PMC7303322
doi:
Types de publication
Case Reports
Langues
eng
Pagination
443Informations de copyright
Copyright © 2020 Specchio, Ferretti, Pietrafusa, Trivisano, Calabrese, Carfì Pavia, De Benedictis, Marras, de Palma and Vigevano.
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