ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation.
adipogenesis
adipose tissue
beige adipocytes
brown adipocyte
estrogen receptor
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
02
2020
accepted:
15
05
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
14
5
2021
Statut:
epublish
Résumé
When exposed to cold temperatures, mice increase their thermogenic capacity by an expansion of brown adipose tissue mass and the formation of brite/beige adipocytes in white adipose tissue depots. However, the process of the transcriptional changes underlying the conversion of a phenotypic white to brite/beige adipocytes is only poorly understood. By analyzing transcriptome profiles of inguinal adipocytes during cold exposure and in mouse models with a different propensity to form brite/beige adipocytes, we identified ESRRG and PERM1 as modulators of this process. The production of heat by mitochondrial uncoupled respiration is a key feature of brite/beige compared to white adipocytes and we show here that both candidates are involved in PGC1α transcriptional network to positively regulate mitochondrial capacity. Moreover, we show that an increased expression of ESRRG or PERM1 supports the formation of brown or brite/beige adipocytes
Identifiants
pubmed: 32595605
doi: 10.3389/fendo.2020.00387
pmc: PMC7304443
doi:
Substances chimiques
Esrrg protein, mouse
0
Muscle Proteins
0
PERM1 protein, mouse
0
Receptors, Estrogen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
387Informations de copyright
Copyright © 2020 Müller, Perdikari, Dapito, Sun, Wollscheid, Balaz and Wolfrum.
Références
Biochim Biophys Acta. 2013 May;1831(5):950-9
pubmed: 23454374
Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E945-64
pubmed: 24549398
J Clin Invest. 2000 Oct;106(7):847-56
pubmed: 11018072
Cell Rep. 2018 Oct 16;25(3):784-797.e4
pubmed: 30332656
Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):9-15
pubmed: 15936182
Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E977-86
pubmed: 19458063
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Am J Clin Nutr. 2011 Apr;93(4):884S-90
pubmed: 21289221
Cell. 2012 Aug 3;150(3):620-32
pubmed: 22863012
J Biol Chem. 2013 Aug 30;288(35):25207-18
pubmed: 23836911
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11870-5
pubmed: 25071184
FASEB J. 2014 Aug;28(8):3745-57
pubmed: 24806198
Bioorg Med Chem. 2015 Jul 1;23(13):3751-60
pubmed: 25910584
Cell Metab. 2007 Jul;6(1):13-24
pubmed: 17618853
Mol Cell Proteomics. 2015 Apr;14(4):841-53
pubmed: 25616865
Nature. 1997 May 1;387(6628):90-4
pubmed: 9139827
Mol Endocrinol. 2010 Feb;24(2):299-309
pubmed: 19965931
Cell. 2014 Jan 16;156(1-2):304-16
pubmed: 24439384
Cell Metab. 2009 Oct;10(4):324-35
pubmed: 19808025
Nature. 2012 Jan 11;481(7382):463-8
pubmed: 22237023
Nature. 1993 Dec 23-30;366(6457):740-2
pubmed: 8264795
Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3665-70
pubmed: 21307310
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Cell. 2012 Jul 20;150(2):366-76
pubmed: 22796012
FEBS Lett. 1984 Feb 13;167(1):10-4
pubmed: 6698197
Mol Metab. 2018 Mar;9:192-198
pubmed: 29396369
Nature. 2008 Aug 21;454(7207):1000-4
pubmed: 18719589
Cell Rep. 2018 Mar 13;22(11):2849-2859
pubmed: 29539415
Cell Metab. 2007 Jul;6(1):38-54
pubmed: 17618855
J Biol Chem. 2015 Mar 27;290(13):8243-55
pubmed: 25645913
Nature. 2013 Mar 21;495(7441):379-83
pubmed: 23485971
J Clin Invest. 2012 Mar;122(3):1022-36
pubmed: 22307324
Cell. 1998 Mar 20;92(6):829-39
pubmed: 9529258
Cell Tissue Res. 1991 Oct;266(1):149-61
pubmed: 1747909
Nat Med. 2013 Oct;19(10):1338-44
pubmed: 23995282
Endocrinology. 2016 Dec;157(12):4770-4781
pubmed: 27763777
Physiol Rev. 2004 Jan;84(1):277-359
pubmed: 14715917
Biochim Biophys Acta. 2014 Sep;1841(9):1345-52
pubmed: 24953778
Cell Rep. 2013 Dec 12;5(5):1196-203
pubmed: 24290753
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
FASEB J. 2015 Jan;29(1):286-99
pubmed: 25392270
Cell Metab. 2014 Sep 2;20(3):396-407
pubmed: 25127354
Cell. 2005 Aug 26;122(4):505-15
pubmed: 16122419
Cell Metab. 2015 Dec 1;22(6):997-1008
pubmed: 26525534
Obesity (Silver Spring). 2013 Mar;21(3):516-24
pubmed: 23404793
Front Endocrinol (Lausanne). 2011 Oct 31;2:64
pubmed: 22654820
J Biol Chem. 2010 Jul 16;285(29):22619-29
pubmed: 20418374
Cell. 2015 Oct 22;163(3):643-55
pubmed: 26496606
Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82
pubmed: 7910436
Nat Cell Biol. 2013 Jun;15(6):659-67
pubmed: 23624403
FASEB J. 2016 Feb;30(2):674-87
pubmed: 26481306
Adipocyte. 2014 Jan 1;3(1):4-9
pubmed: 24575363
Cell Rep. 2015 Mar 17;10(10):1681-1691
pubmed: 25772356
iScience. 2018 Apr 27;2:221-237
pubmed: 29888756
Cell Metab. 2014 Apr 1;19(4):593-604
pubmed: 24703692
Bioessays. 2002 Apr;24(4):382-8
pubmed: 11948624
J Cell Sci. 1992 Dec;103 ( Pt 4):931-42
pubmed: 1362571
Nat Rev Endocrinol. 2014 Jan;10(1):24-36
pubmed: 24146030
Genes Dev. 2012 Feb 1;26(3):271-81
pubmed: 22302939