The association Between Occupational Exposure to silica and Risk of Developing Rheumatoid Arthritis: A Meta-Analysis.
Meta-analysis
Occupation
Rheumatoid arthritis
Silica exposure
Journal
Safety and health at work
ISSN: 2093-7911
Titre abrégé: Saf Health Work
Pays: Korea (South)
ID NLM: 101542940
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
21
12
2019
revised:
31
01
2020
accepted:
22
02
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
1
7
2020
Statut:
ppublish
Résumé
Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory arthritis. This meta-analysis was conducted to examine the association between occupational exposure to silica and the risk of developing RA among different workers. In this meta-analysis, we searched relevant published studies using major electronic databases including Scopus, PubMed, ISI Web of Science, and Google Scholar search engine up to October 2019, and the references of retrieved articles were also checked for further possible sources. A random-effects model was used to account for heterogeneity among the results of the studies using the pooled odds ratios (ORs) and their 95% confidence intervals (CIs). The Q-statistic and I The pooled calculation of OR indicated a significant association between occupational exposure to silica and risk of developing RA among different workers (OR = 2.59, 95% CI = 1.73 to 3.45). In addition, the pooled estimates of OR in smokers were statistically significant (OR = 2.49, 95% CI = 1.13 to 3.86). The findings of the present study reveal that occupational exposure to silica may be associated with increased risk of developing RA.
Sections du résumé
BACKGROUND
BACKGROUND
Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory arthritis. This meta-analysis was conducted to examine the association between occupational exposure to silica and the risk of developing RA among different workers.
METHODS
METHODS
In this meta-analysis, we searched relevant published studies using major electronic databases including Scopus, PubMed, ISI Web of Science, and Google Scholar search engine up to October 2019, and the references of retrieved articles were also checked for further possible sources. A random-effects model was used to account for heterogeneity among the results of the studies using the pooled odds ratios (ORs) and their 95% confidence intervals (CIs). The Q-statistic and I
RESULTS
RESULTS
The pooled calculation of OR indicated a significant association between occupational exposure to silica and risk of developing RA among different workers (OR = 2.59, 95% CI = 1.73 to 3.45). In addition, the pooled estimates of OR in smokers were statistically significant (OR = 2.49, 95% CI = 1.13 to 3.86).
CONCLUSIONS
CONCLUSIONS
The findings of the present study reveal that occupational exposure to silica may be associated with increased risk of developing RA.
Identifiants
pubmed: 32596007
doi: 10.1016/j.shaw.2020.02.001
pii: S2093-7911(19)30874-1
pmc: PMC7303526
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
136-142Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
Références
PLoS Med. 2009 Jul 21;6(7):e1000100
pubmed: 19621070
Environ Health Perspect. 2005 Mar;113(3):255-60
pubmed: 15743711
Am J Ind Med. 1995 Feb;27(2):217-29
pubmed: 7755012
Am J Med. 2006 Jun;119(6):503.e1-9
pubmed: 16750964
Am J Med. 2015 Oct;128(10):1094-101
pubmed: 26007670
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Lung Cancer. 2002 Sep;37(3):241-56
pubmed: 12234692
Scand J Work Environ Health. 2000 Jun;26(3):243-9
pubmed: 10901117
J Immunotoxicol. 2005 Jul 1;1(3):177-87
pubmed: 18958651
Semin Immunol. 2011 Apr;23(2):92-8
pubmed: 21376627
Int J Biochem Cell Biol. 2010 Feb;42(2):230-40
pubmed: 19836462
Rev Environ Health. 2002 Oct-Dec;17(4):307-15
pubmed: 12611472
Environ Health Perspect. 2008 Jun;116(6):695-702
pubmed: 18560522
Arthritis Res. 2002;4 Suppl 3:S265-72
pubmed: 12110146
Ann Rheum Dis. 2011 Mar;70(3):508-11
pubmed: 21149499
Ann Rheum Dis. 2018 Aug;77(8):1238-1241
pubmed: 28916713
Curr Rheumatol Rep. 2011 Oct;13(5):431-9
pubmed: 21785978
Environ Health Perspect. 1999 Oct;107 Suppl 5:793-802
pubmed: 10970168
Br Med J (Clin Res Ed). 1987 Apr 18;294(6578):997-1000
pubmed: 2823951
Arthritis Rheum. 2000 Jan;43(1):30-7
pubmed: 10643697
Ann Rheum Dis. 2010 Jan;69(1):54-60
pubmed: 19151010
Rheum Dis Clin North Am. 1992 Nov;18(4):741-59
pubmed: 1280845
BMJ Open. 2017 Jul 20;7(7):e016839
pubmed: 28729325
Ann Rheum Dis. 2005 Apr;64(4):582-6
pubmed: 15319232
Ann Rheum Dis. 2010 Jun;69(6):1072-6
pubmed: 19966090
Occup Environ Med. 2004 Mar;61(3):233-8
pubmed: 14985518
Environ Health Perspect. 2006 Aug;114(8):1243-7
pubmed: 16882533
J Autoimmun. 2012 May;38(2-3):J177-86
pubmed: 22137891
Occup Environ Med. 2000 Jul;57(7):443-7
pubmed: 10854495
Mod Rheumatol. 2014 Mar;24(2):271-4
pubmed: 24593203
Front Immunol. 2015 Feb 11;6:60
pubmed: 25717329
Ann Rheum Dis. 2016 Jun;75(6):997-1002
pubmed: 26681695