Differentiating anxiety from fear: an experimental-pharmacological approach.
Anxiety
Fear
Lorazepam
Revised-reinforcement-sensitivity-theory
Journal
Personality neuroscience
ISSN: 2513-9886
Titre abrégé: Personal Neurosci
Pays: England
ID NLM: 101718316
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
07
2019
revised:
13
01
2020
accepted:
22
01
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
1
7
2020
Statut:
epublish
Résumé
Gray's theory of personality postulates that fear and anxiety are distinct emotional systems with only the latter being sensitive to anxiolytic drugs. His work was mainly based on animal research, and translational studies validating his theory are scarce. Previous work in humans showed an influence of the benzodiazepine lorazepam on both systems, however, dependent on dosage (1 and 2 mg) and personality differences in negative emotionality. The present study aims to replicate these findings, and in addition tests the drug threshold effect by introducing a lower dosage of 0.5 mg lorazepam. Fifty healthy adults (23 males, age
Identifiants
pubmed: 32596627
doi: 10.1017/pen.2020.1
pmc: PMC7303801
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e6Informations de copyright
© The Author(s) 2020.
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