Bioactive fluorenes. Part III: 2,7-dichloro-9
Anti-cancer
Antimicrobial
Azetidinones
FACS
Fluorene
Molecular docking
Pharmacophores
Thiazolidinones
Journal
BMC chemistry
ISSN: 2661-801X
Titre abrégé: BMC Chem
Pays: Switzerland
ID NLM: 101741142
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
19
03
2020
accepted:
17
06
2020
entrez:
30
6
2020
pubmed:
1
7
2020
medline:
1
7
2020
Statut:
epublish
Résumé
Thiazoles, thiazolidinones and azetidinones are highly ranked amongst natural and synthetic heterocyclic derivatives due to their great pharmaceutical potential. New thiazolidinone and azetidinone class of bioactive agents based on 4-(2,7-dichloro-9 Some of the synthesized compounds showed remarkable activity against A-549 and MDA-MB-231 when compared to Taxol, which was used as a reference drug. 2,7-dichloro-9
Sections du résumé
BACKGROUND
BACKGROUND
Thiazoles, thiazolidinones and azetidinones are highly ranked amongst natural and synthetic heterocyclic derivatives due to their great pharmaceutical potential.
RESULTS
RESULTS
New thiazolidinone and azetidinone class of bioactive agents based on 4-(2,7-dichloro-9
CONCLUSION
CONCLUSIONS
Some of the synthesized compounds showed remarkable activity against A-549 and MDA-MB-231 when compared to Taxol, which was used as a reference drug. 2,7-dichloro-9
Identifiants
pubmed: 32596690
doi: 10.1186/s13065-020-00694-2
pii: 694
pmc: PMC7315563
doi:
Types de publication
Journal Article
Langues
eng
Pagination
42Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing of interestsThe authors declare that they have no competing interests.
Références
Curr Cancer Drug Targets. 2018;18(4):372-381
pubmed: 28669339
Eur J Med Chem. 2016 Oct 21;122:196-204
pubmed: 27371923
Bioorg Med Chem Lett. 2014 Dec 1;24(23):5428-31
pubmed: 25453802
J Med Chem. 1992 Jul 24;35(15):2910-2
pubmed: 1353796
Eur J Med Chem. 2016 Nov 10;123:309-316
pubmed: 27484516
Biochem Pharmacol. 2006 Mar 30;71(7):941-8
pubmed: 16359642
Future Med Chem. 2015;7(4):459-71
pubmed: 25875873
Heliyon. 2019 Jun 26;5(6):e01982
pubmed: 31304415
Eur J Med Chem. 2018 Jan 1;143:532-541
pubmed: 29207336
Eur J Med Chem. 2012 Mar;49:172-82
pubmed: 22280817
J Med Chem. 1985 Nov;28(11):1621-8
pubmed: 4067990
Bioorg Med Chem. 2011 Aug 1;19(15):4562-73
pubmed: 21723734
BMC Chem. 2019 Jul 11;13(1):91
pubmed: 31384838
Faraday Discuss. 1992;(93):217-24
pubmed: 1290933
Nat Protoc. 2008;3(2):163-75
pubmed: 18274517
Experientia. 1982 Apr 15;38(4):436-7
pubmed: 7044814
Eur J Med Chem. 2013 Apr;62:508-14
pubmed: 23416192
Bioorg Med Chem. 1999 Jun;7(6):1105-10
pubmed: 10428380
Springerplus. 2016 Jun 24;5(1):887
pubmed: 27386335
Chem Cent J. 2015 May 10;9:25
pubmed: 25995769
Chem Biol Interact. 2008 Feb 15;171(3):363-8
pubmed: 18053977
Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 25;66(Pt 10):o2624-5
pubmed: 21587598
Ann Clin Microbiol Antimicrob. 2015 May 18;14:28
pubmed: 25982441
Microb Drug Resist. 2019 Jul/Aug;25(6):890-908
pubmed: 30811275
Bioorg Med Chem. 2007 Apr 15;15(8):3089-96
pubmed: 17317192
Bioorg Med Chem Lett. 2016 Nov 1;26(21):5361-5368
pubmed: 27546293
Eur J Med Chem. 2012 Mar;49:164-71
pubmed: 22264895
Bioorg Chem. 2017 Apr;71:19-29
pubmed: 28143658
Eur J Med Chem. 2010 Jul;45(7):2777-83
pubmed: 20392546