Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA

Aging, Premature Animals DNA Polymerase gamma / metabolism Disease Models, Animal Female Frailty Humans Mice Sarcopenia / genetics
Aging Osteopenia Osteosarcopenia Sarcopenia in vivo micro-CT mTORC1

Journal

Journal of cachexia, sarcopenia and muscle
ISSN: 2190-6009
Titre abrégé: J Cachexia Sarcopenia Muscle
Pays: Germany
ID NLM: 101552883

Informations de publication

Date de publication:
08 2020
Historique:
received: 19 09 2019
revised: 14 02 2020
accepted: 24 02 2020
pubmed: 1 7 2020
medline: 26 8 2021
entrez: 30 6 2020
Statut: ppublish

Résumé

Frailty is a geriatric syndrome characterized by increased susceptibility to adverse health outcomes. One major determinant thereof is the gradual weakening of the musculoskeletal system and the associated osteosarcopenia. To improve our understanding of the underlying pathophysiology and, more importantly, to test potential interventions aimed at counteracting frailty, suitable animal models are needed. To evaluate the relevance of prematurely aged PolgA PolgA PolgA

Sections du résumé

BACKGROUND
Frailty is a geriatric syndrome characterized by increased susceptibility to adverse health outcomes. One major determinant thereof is the gradual weakening of the musculoskeletal system and the associated osteosarcopenia. To improve our understanding of the underlying pathophysiology and, more importantly, to test potential interventions aimed at counteracting frailty, suitable animal models are needed.
METHODS
To evaluate the relevance of prematurely aged PolgA
RESULTS
PolgA
CONCLUSIONS
PolgA

Identifiants

DOI: 10.1002/jcsm.12588 PMID: 32596975 PMC: PMC7432580
pubmed: 32596975
doi: 10.1002/jcsm.12588
pmc: PMC7432580
doi:

Substances chimiques

DNA Polymerase gamma EC 2.7.7.7
Polg protein, mouse EC 2.7.7.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1121-1140

Informations de copyright

© 2020 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

Références

J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):384-399
pubmed: 29399988
J Orthop Res. 2017 Jul;35(7):1375-1382
pubmed: 27572850
J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):333-9
pubmed: 25711530
Calcif Tissue Int. 1995 Jul;57(1):35-9
pubmed: 7671163
J Physiol. 2013 Sep 15;591(18):4611-20
pubmed: 23732640
EJNMMI Res. 2011 Jul 29;1(1):11
pubmed: 22214535
Physiol Rev. 2013 Jan;93(1):23-67
pubmed: 23303905
J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):489-95
pubmed: 26718984
Sci Transl Med. 2012 Jul 25;4(144):144ra103
pubmed: 22837538
Nat Protoc. 2020 Feb;15(2):540-574
pubmed: 31915391
Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
Bone. 2013 Aug;55(2):335-46
pubmed: 23643681
Mitochondrion. 2013 Jul;13(4):282-91
pubmed: 23542163
Free Radic Biol Med. 2014 Oct;75:241-51
pubmed: 25106705
J Cell Biochem. 2008 Feb 1;103(2):434-46
pubmed: 17516572
Exerc Sport Sci Rev. 2019 Jul;47(3):188-194
pubmed: 30870215
Nutr Metab (Lond). 2011 Oct 05;8:68
pubmed: 21975196
Arch Gerontol Geriatr. 2017 Mar - Apr;69:134-143
pubmed: 27918964
J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):1143-1145
pubmed: 31661195
FEBS J. 2013 Sep;280(17):4294-314
pubmed: 23517348
Bone. 2011 Oct;49(4):613-22
pubmed: 21763477
PLoS Genet. 2014 Jan 30;10(1):e1004145
pubmed: 24497849
J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):62-7
pubmed: 22511289
PLoS One. 2017 Jun 15;12(6):e0179588
pubmed: 28617851
ILAR J. 2008;49(1):17-26
pubmed: 18172330
Cell Rep. 2013 Sep 12;4(5):913-20
pubmed: 23994476
Acta Physiol (Oxf). 2013 Jul;208(3):251-64
pubmed: 23418947
Am J Clin Nutr. 2005 Nov;82(5):1065-73
pubmed: 16280440
Curr Opin Clin Nutr Metab Care. 2008 May;11(3):222-6
pubmed: 18403916
Front Physiol. 2019 Oct 04;10:1271
pubmed: 31636571
Aging Cell. 2019 Jun;18(3):e12943
pubmed: 30924297
Elife. 2019 Apr 23;8:
pubmed: 31012848
Bone. 1995 Oct;17(4 Suppl):145S-154S
pubmed: 8579910
Orthod Craniofac Res. 2019 May;22 Suppl 1:90-95
pubmed: 31074146
Calcif Tissue Int. 2010 Jun;86(6):470-83
pubmed: 20405109
J Biomech. 2015 Apr 13;48(6):1179-87
pubmed: 25543278
J Bone Miner Res. 1987 Dec;2(6):595-610
pubmed: 3455637
Osteoporos Int. 2017 Oct;28(10):2781-2790
pubmed: 28733716
Best Pract Res Clin Rheumatol. 2014 Jun;28(3):395-410
pubmed: 25481423
J Bone Miner Res. 2007 Aug;22(8):1197-207
pubmed: 17488199
Bone. 2011 Mar 1;48(3):433-42
pubmed: 20950723
J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):722-7
pubmed: 17634318
Front Physiol. 2017 Oct 17;8:788
pubmed: 29089899
J Physiol. 2009 Jul 15;587(Pt 14):3691-701
pubmed: 19470781
Front Genet. 2015 Feb 20;6:59
pubmed: 25750654
Biogerontology. 2013 Jun;14(3):273-92
pubmed: 23666344
Methods Mol Biol. 2019;1914:411-435
pubmed: 30729480
Nat Med. 2012 Jul;18(7):1095-101
pubmed: 22729283
Nutrients. 2016 Jan 15;8(1):
pubmed: 26784225
J Exp Biol. 2013 Jul 15;216(Pt 14):2619-31
pubmed: 23531822
J Bone Miner Res. 2017 Aug;32(8):1599-1606
pubmed: 28460152
Sci Rep. 2017 Feb 21;7:43068
pubmed: 28220898
J Physiol. 2003 Mar 15;547(Pt 3):977-87
pubmed: 12562918
Bone. 2007 Oct;41(4):659-67
pubmed: 17662679
Bone. 2014 Sep;66:15-25
pubmed: 24882735
Best Pract Res Clin Rheumatol. 2017 Apr;31(2):145-159
pubmed: 29224693
Bone. 2011 Dec;49(6):1340-50
pubmed: 21964411
Bone. 2011 Apr 1;48(4):952-7
pubmed: 21195216
Front Aging Neurosci. 2018 Jun 12;10:172
pubmed: 29946252
Mech Ageing Dev. 2019 Jun;180:11-20
pubmed: 30885572
J Bone Miner Res. 2008 Dec;23(12):2048-59
pubmed: 18684086
Cell Cycle. 2006 Jul;5(13):1391-6
pubmed: 16855395
J Am Geriatr Soc. 2004 Nov;52(11):1929-33
pubmed: 15507074
J Nutr Health Aging. 2015 Apr;19(4):474-80
pubmed: 25809813
J Gerontol A Biol Sci Med Sci. 2012 Mar;67(3):217-27
pubmed: 22021390
Mol Ther Methods Clin Dev. 2019 May 30;14:64-76
pubmed: 31312666
Skelet Muscle. 2018 Aug 6;8(1):25
pubmed: 30081940
Biochem Biophys Res Commun. 2015 Dec 25;468(4):702-7
pubmed: 26551463
Mech Ageing Dev. 2019 Apr;179:1-10
pubmed: 30703384
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
FASEB J. 2005 Mar;19(3):422-4
pubmed: 15596483
Science. 2005 Jul 15;309(5733):481-4
pubmed: 16020738
Aging Cell. 2019 Dec;18(6):e13029
pubmed: 31489782
Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E151-7
pubmed: 16926381
Comput Methods Biomech Biomed Engin. 2008 Oct;11(5):435-41
pubmed: 18612871
PLoS One. 2012;7(4):e34980
pubmed: 22514696
Bone. 2014 Aug;65:83-91
pubmed: 24836737
Calcif Tissue Int. 1996 Jan;58(1):24-9
pubmed: 8825235
Skelet Muscle. 2011 Mar 02;1(1):11
pubmed: 21798089
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4135-40
pubmed: 21368114
J Cachexia Sarcopenia Muscle. 2016 Dec;7(5):547-554
pubmed: 27239425
Bone. 1992;13(3):205-8
pubmed: 1637566
J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):621-32
pubmed: 24051346
J Biol Chem. 2017 Jan 6;292(1):196-204
pubmed: 27879318
Med Eng Phys. 2008 Sep;30(7):888-95
pubmed: 18249025
Mol Cell Biol. 2019 Sep 11;39(19):
pubmed: 31308131
Nature. 2004 May 27;429(6990):417-23
pubmed: 15164064
J Cachexia Sarcopenia Muscle. 2020 Aug;11(4):1121-1140
pubmed: 32596975
J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):897-903
pubmed: 28158648
J Am Med Dir Assoc. 2014 Aug;15(8):551-8
pubmed: 24703927
Bone. 2011 Sep;49(3):439-46
pubmed: 21642027
Aust Fam Physician. 2017 Nov;46(11):849-853
pubmed: 29101922

Auteurs

Ariane C Scheuren (AC)

Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.

Gommaar D'Hulst (G)

Laboratory of Exercise and Health, ETH Zurich, Zurich, Switzerland.

Gisela A Kuhn (GA)

Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.

Evi Masschelein (E)

Laboratory of Exercise and Health, ETH Zurich, Zurich, Switzerland.

Esther Wehrle (E)

Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.

Katrien De Bock (K)

Laboratory of Exercise and Health, ETH Zurich, Zurich, Switzerland.

Ralph Müller (R)

Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.
ORCID: 0000-0002-5811-7725

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Vieillissement précoce › Hallmarks of frailty and osteosarcopenia in...
questionsmedicales.fr › Eucaryotes › Animaux › Hallmarks of frailty and osteosarcopenia in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › DNA Polymerase gamma › Hallmarks of frailty and osteosarcopenia in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Hallmarks of frailty and osteosarcopenia in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › Hallmarks of frailty and osteosarcopenia in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hallmarks of frailty and osteosarcopenia in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hallmarks of frailty and osteosarcopenia in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Sarcopénie › Hallmarks of frailty and osteosarcopenia in...