Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1
Administration, Oral
Animals
Cerebral Cortex
/ drug effects
Drug Evaluation, Preclinical
Free Radical Scavengers
/ chemistry
Kidney
/ drug effects
Lipid Peroxidation
/ drug effects
Liver
/ drug effects
Male
Mice
Models, Animal
Pyrazoles
/ chemistry
Reactive Oxygen Species
/ metabolism
Selenium
/ chemistry
Sulfur
/ chemistry
Toxicity Tests, Acute
antioxidant
antioxydant
organoselenium
organosélénium
oxidative stress
pyrazoles
stress oxydatif
toxicity
toxicité
Journal
Canadian journal of physiology and pharmacology
ISSN: 1205-7541
Titre abrégé: Can J Physiol Pharmacol
Pays: Canada
ID NLM: 0372712
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
pubmed:
1
7
2020
medline:
9
2
2021
entrez:
30
6
2020
Statut:
ppublish
Résumé
Pyrazoles represent a significant class of heterocyclic compounds that exhibit pharmacological properties. The present study aimed to investigate the antioxidant potential of pyrazol derivative compounds in brain of mice in vitro and the effect of pyrazol derivative compounds in the oxidative damage and toxicity parameters in mouse brain and plasma of mice. The compounds tested were 3,5-dimethyl-1-phenyl-4-(phenylselanyl)-1
Identifiants
pubmed: 32597688
doi: 10.1139/cjpp-2019-0356
doi:
Substances chimiques
Free Radical Scavengers
0
Pyrazoles
0
Reactive Oxygen Species
0
Sulfur
70FD1KFU70
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM