Novel Isatin Thiosemicarbazone Derivatives as Potent Inhibitors of β-Amyloid Peptide Aggregation and Toxicity.
Alzheimer’s disease
Antioxidant activity
Circular dichroism spectropolarimetry
Inhibitors of β-amyloid aggregation
Isatin thiosemicarbazones
Primary neuronal cell cultures
β-Amyloid peptide
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
05 08 2020
05 08 2020
Historique:
pubmed:
1
7
2020
medline:
22
6
2021
entrez:
30
6
2020
Statut:
ppublish
Résumé
Inhibition of β-amyloid peptide (Αβ) aggregation in Alzheimer's disease (AD) is among the therapeutic approaches against AD which still attracts scientific research interest. In the search for compounds that interact with Aβ and disrupt its typical aggregation course toward oligomeric or polymeric toxic assemblies, small organic molecules of natural origin, combining low molecular weight (necessary blood-brain barrier penetration) and low toxicity (necessary for pharmacological application), are greatly sought after. Isatin (1
Identifiants
pubmed: 32598129
doi: 10.1021/acschemneuro.0c00208
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
Thiosemicarbazones
0
Isatin
82X95S7M06
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM