Ontogenetic changes in the venom of Metlapilcoatlus nummifer, the mexican jumping viper.
Antivenom
Atropoides
Ontogenetic
Phospholipase A(2)
Snake venom
Journal
Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
11
04
2020
revised:
03
06
2020
accepted:
23
06
2020
pubmed:
1
7
2020
medline:
28
8
2020
entrez:
30
6
2020
Statut:
ppublish
Résumé
The viperid genus Metlapilcoatlus (previously Atropoides) is represented in Mexico by four species: M. olmec, M. mexicanus, M. occidus, and M. nummifer. To date, no studies on their venoms have been reported. Here, we comparatively characterized the venom from M. nummifer neonates (≤8 months of age), young adults (18 months) and adults (≥24 months). We performed biological and enzymatic activities, as well as electrophoretic and RP-HPLC profiling combined with proteomic assignment of major fractions. Venoms from neonates and adults differed in their electrophoretic and chromatographic profiles, indicating that an ontogenetic compositional shift occurs in this species. Protein family assignments showed that neonates produce a venom rich in Snake Venom Metalloproteinases (SVMPs) and Snake Venom Serine Proteases (SVSPs), but lacking Phospholipases A
Identifiants
pubmed: 32598990
pii: S0041-0101(20)30302-0
doi: 10.1016/j.toxicon.2020.06.023
pii:
doi:
Substances chimiques
Crotalid Venoms
0
Proteome
0
Phospholipases A2
EC 3.1.1.4
Metalloproteases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
204-214Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.