Rosuvastatin based novel 3-substituted isocoumarins / 3-alkylidenephthalides: Ultrasound assisted synthesis and identification of new anticancer agents.
Animals
Antineoplastic Agents
/ chemical synthesis
Benzofurans
/ chemical synthesis
Cell Line, Tumor
Drug Screening Assays, Antitumor
Embryo, Nonmammalian
/ drug effects
Humans
Isocoumarins
/ chemical synthesis
Molecular Structure
Rosuvastatin Calcium
/ analogs & derivatives
Structure-Activity Relationship
Ultrasonic Waves
Zebrafish
Cancer
Isocoumarin
Phthalide
Rosuvastatin
Zebrafish
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
27
12
2019
revised:
25
03
2020
accepted:
13
04
2020
pubmed:
1
7
2020
medline:
7
4
2021
entrez:
30
6
2020
Statut:
ppublish
Résumé
A new class of 3-substituted isocoumarin/3-alkylidenephthalide based novel small molecules derived from rosuvastatin were designed and synthesized via the ultrasound assisted Cu-mediated coupling-cyclization in a single pot with remarkable regioselectivity. The phthalides were generally obtained at lower temperature whereas the use of elevated temperature afforded isocoumarins. Two compounds e.g. 3n and 4d showed promising cytotoxic effects when tested against HCT 116, HepG2 and PA-1 cell lines at 10 μM. Indeed, 4d was found to be a potent cytotoxic agent (IC
Identifiants
pubmed: 32599323
pii: S0223-5234(20)30304-4
doi: 10.1016/j.ejmech.2020.112335
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Benzofurans
0
Isocoumarins
0
Rosuvastatin Calcium
83MVU38M7Q
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112335Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.