MicroRNA-5572 Is a Novel MicroRNA-Regulating
amyotrophic lateral sclerosis
microRNA
microarray
spinal cord
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Jun 2020
24 Jun 2020
Historique:
received:
28
05
2020
revised:
19
06
2020
accepted:
22
06
2020
entrez:
1
7
2020
pubmed:
1
7
2020
medline:
23
3
2021
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease caused by the loss of motor neurons. Although the pathogenesis of sporadic ALS (sALS) remains unclear, it has recently been suggested that disorders of microRNA (miRNA) may be involved in neurodegenerative conditions. The purpose of this study was to investigate miRNA levels in sALS and the target genes of miRNA. Microarray and real-time RT-PCR analyses revealed significantly-decreased levels of miR-139-5p and significantly increased levels of miR-5572 in the spinal cords of sALS patients compared with those in controls. We then focused on miR-5572, which has not been reported in ALS, and determined its target gene. By using TargetScan, we predicted
Identifiants
pubmed: 32599739
pii: ijms21124482
doi: 10.3390/ijms21124482
pmc: PMC7350020
pii:
doi:
Substances chimiques
Biomarkers
0
Cation Transport Proteins
0
MicroRNAs
0
SLC30A3 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 15K21278
Organisme : Japan Society for the Promotion of Science
ID : 17K18001
Organisme : Japan Society for the Promotion of Science
ID : JP19H05767A02
Organisme : the Collaborative Research Project of Brain Research Institute, Niigata University
ID : 2019-23
Organisme : Grant-in-Aid of The Nakabayashi Trust For ALS Research
ID : 28-16
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