Development of a Deep Learning Algorithm for Periapical Disease Detection in Dental Radiographs.

artificial intelligence computer-assisted diagnosis image interpretation machine learning panoramic radiograph radiography

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
24 Jun 2020
Historique:
received: 25 05 2020
revised: 18 06 2020
accepted: 19 06 2020
entrez: 1 7 2020
pubmed: 1 7 2020
medline: 1 7 2020
Statut: epublish

Résumé

Periapical radiolucencies, which can be detected on panoramic radiographs, are one of the most common radiographic findings in dentistry and have a differential diagnosis including infections, granuloma, cysts and tumors. In this study, we seek to investigate the ability with which 24 oral and maxillofacial (OMF) surgeons assess the presence of periapical lucencies on panoramic radiographs, and we compare these findings to the performance of a predictive deep learning algorithm that we have developed using a curated data set of 2902 de-identified panoramic radiographs. The mean diagnostic positive predictive value (PPV) of OMF surgeons based on their assessment of panoramic radiographic images was 0.69(± 0.13), indicating that dentists on average falsely diagnose 31% of cases as radiolucencies. However, the mean diagnostic true positive rate (TPR) was 0.51(± 0.14), indicating that on average 49% of all radiolucencies were missed. We demonstrate that the deep learning algorithm achieves a better performance than 14 of 24 OMF surgeons within the cohort, exhibiting an average precision of 0.60(± 0.04), and an F

Identifiants

pubmed: 32599942
pii: diagnostics10060430
doi: 10.3390/diagnostics10060430
pmc: PMC7344682
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Eric and Wendy Schmidt Family Foundation
ID : 0000

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Auteurs

Michael G Endres (MG)

Laboratory for Innovation Science, Harvard University, 175 N. Harvard Street, Suite 1350, Boston, MA 02134, USA.

Florian Hillen (F)

Laboratory for Innovation Science, Harvard University, 175 N. Harvard Street, Suite 1350, Boston, MA 02134, USA.
Institute for Data, Systems and Society, Massachusetts Institute of Technology, 50 Ames St, Cambridge, MA 02142, USA.

Marios Salloumis (M)

Department of Oral- and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany.

Ahmad R Sedaghat (AR)

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Medical Sciences Building Room 6410, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

Stefan M Niehues (SM)

Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany.

Olivia Quatela (O)

Department of Oral- and Maxillofacial Surgery, Universitätsklinikum Hamburg, Eppendorf, Maritnistraße 52, 20246 Hamburg, Germany.

Henning Hanken (H)

Department of Oral- and Maxillofacial Surgery, Universitätsklinikum Hamburg, Eppendorf, Maritnistraße 52, 20246 Hamburg, Germany.

Ralf Smeets (R)

Department of Oral- and Maxillofacial Surgery, Universitätsklinikum Hamburg, Eppendorf, Maritnistraße 52, 20246 Hamburg, Germany.

Benedicta Beck-Broichsitter (B)

Department of Oral- and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany.

Carsten Rendenbach (C)

Department of Oral- and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany.

Karim Lakhani (K)

Laboratory for Innovation Science, Harvard University, 175 N. Harvard Street, Suite 1350, Boston, MA 02134, USA.
Technology and Operations Management Unit, Harvard Business School, Wyss House, Boston, MA 02163, USA.

Max Heiland (M)

Department of Oral- and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany.

Robert A Gaudin (RA)

Laboratory for Innovation Science, Harvard University, 175 N. Harvard Street, Suite 1350, Boston, MA 02134, USA.
Department of Oral- and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany.

Classifications MeSH