Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches.
chemokines
chronic inflammation
dendritic cells
immune system
lymphocytes
tertiary lymphoid organs
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
12
03
2020
revised:
21
05
2020
accepted:
04
06
2020
pubmed:
1
7
2020
medline:
16
10
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Chronic inflammation is the result a persistent increase in the expression of several proinflammatory pathways with impaired inflammatory resolution. Ectopic lymphoid organs (ELOs), untypical lymphoid annexes, emerge during chronic inflammation and contribute to the physiopathology of chronic inflammatory disorders. This review discusses the pathophysiological role of ELOs in the progression of immune-mediated inflammatory diseases (IMIDs), including multiple sclerosis (MS), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), atherosclerosis, and Sjögren syndrome (SSj). The molecular pathways underlying the emergence of ELOs are of interest for the development of novel pharmacological approaches for the management of chronic inflammatory diseases.
Identifiants
pubmed: 32600794
pii: S1471-4914(20)30155-6
doi: 10.1016/j.molmed.2020.06.004
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1021-1033Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.