Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax.

Animals Antimalarials / pharmacology Drug Repositioning Epirubicin / therapeutic use Malaria, Vivax / drug therapy Mice Plasmodium falciparum / genetics Plasmodium vivax / genetics
DNA gyrase chemogenomics drug repositioning epirubicin malaria

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
20 08 2020
Historique:
received: 11 10 2019
accepted: 19 06 2020
pubmed: 1 7 2020
medline: 22 6 2021
entrez: 1 7 2020
Statut: epublish

Résumé

Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduce costs, risks, and time-to-market. Herein, we have used this strategy to identify novel antimalarial hits. We used a comparative

Identifiants

DOI: 10.1128/AAC.02041-19 PMID: 32601162 PMC: PMC7449180
pubmed: 32601162
pii: AAC.02041-19
doi: 10.1128/AAC.02041-19
pmc: PMC7449180
pii:
doi:

Substances chimiques

Antimalarials 0
Epirubicin 3Z8479ZZ5X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Letícia Tiburcio Ferreira (LT)

Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.

Juliana Rodrigues (J)

Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Gustavo Capatti Cassiano (GC)

Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
ORCID: 0000-0002-6971-5974

Tatyana Almeida Tavella (TA)

Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.

Kaira Cristina Peralis Tomaz (KCP)

Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.

Djane Clarys Baia-da-Silva (DC)

Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz-FIOCRUZ, Manaus, Amazonas, Brazil.

Macejane Ferreira Souza (MF)

Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz-FIOCRUZ, Manaus, Amazonas, Brazil.
Fundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.

Marilia Nunes do Nascimento Lima (MNDN)

Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Melina Mottin (M)

Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Ludimila Dias Almeida (LD)

Synthetic Biology Laboratory, Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, São Paulo, Brazil.

Juliana Calit (J)

Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-USP, São Paulo, Brazil.

Maria Carolina Silva de Barros Puça (MCSB)

Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz-FIOCRUZ, Manaus, Amazonas, Brazil.

Gisely Cardoso Melo (GC)

Fundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.

Daniel Youssef Bargieri (DY)

Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo-USP, São Paulo, Brazil.

Stefanie Costa Pinto Lopes (SCP)

Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz-FIOCRUZ, Manaus, Amazonas, Brazil.
Fundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
ORCID: 0000-0002-6981-2192

Marcus Vinicius Guimarães Lacerda (MVG)

Fundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.

Elizabeth Bilsland (E)

Synthetic Biology Laboratory, Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, São Paulo, Brazil.

Per Sunnerhagen (P)

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0002-0967-8729

Bruno Junior Neves (BJ)

Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
LabChem-Laboratory of Cheminformatics, Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis, Goiás, Brazil.

Carolina Horta Andrade (CH)

Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil carolhandrade@gmail.com pedrovcravo@gmail.com fabiotmc72@gmail.com.
Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Pedro Vitor Lemos Cravo (PVL)

Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal carolhandrade@gmail.com pedrovcravo@gmail.com fabiotmc72@gmail.com.
LabChem-Laboratory of Cheminformatics, Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis, Goiás, Brazil.

Fabio Trindade Maranhão Costa (FTM)

Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil carolhandrade@gmail.com pedrovcravo@gmail.com fabiotmc72@gmail.com.
ORCID: 0000-0001-9969-7300

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Computational Chemogenomics Drug Repositioning...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Computational Chemogenomics Drug Repositioning...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Repositionnement des médicaments › Computational Chemogenomics Drug Repositioning...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Épirubicine › Computational Chemogenomics Drug Repositioning...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium vivax › Computational Chemogenomics Drug Repositioning...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Computational Chemogenomics Drug Repositioning...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Computational Chemogenomics Drug Repositioning...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium vivax › Computational Chemogenomics Drug Repositioning...