Channelopathies of voltage-gated L-type Cav1.3/α
Ca2+ channels
Cav1.3
Cav3.1
Sinus node
Sinus node dysfunction
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
08
04
2020
accepted:
19
06
2020
revised:
12
06
2020
pubmed:
1
7
2020
medline:
9
6
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
The heart automaticity is a fundamental physiological function in vertebrates. The cardiac impulse is generated in the sinus node by a specialized population of spontaneously active myocytes known as "pacemaker cells." Failure in generating or conducting spontaneous activity induces dysfunction in cardiac automaticity. Several families of ion channels are involved in the generation and regulation of the heart automaticity. Among those, voltage-gated L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca
Identifiants
pubmed: 32601767
doi: 10.1007/s00424-020-02421-1
pii: 10.1007/s00424-020-02421-1
doi:
Substances chimiques
Calcium Channels, L-Type
0
Calcium Channels, T-Type
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
817-830Commentaires et corrections
Type : ErratumIn