A design process for a 3D printed patient-specific applicator for HDR brachytherapy of the orbit.
Applicator
Brachytherapy
High dose-rate
Patient-specific
Journal
3D printing in medicine
ISSN: 2365-6271
Titre abrégé: 3D Print Med
Pays: England
ID NLM: 101721758
Informations de publication
Date de publication:
29 Jun 2020
29 Jun 2020
Historique:
received:
11
03
2020
accepted:
15
06
2020
entrez:
1
7
2020
pubmed:
1
7
2020
medline:
1
7
2020
Statut:
epublish
Résumé
This report describes a process for designing a 3D printed patient-specific applicator for HDR brachytherapy of the orbit. A 34-year-old man with recurrent melanoma of the orbit was referred for consideration of re-irradiation. An applicator for HDR brachytherapy was designed based on the computed tomography (CT) of patient anatomy. The body contour was used to generate an applicator with a flush fit against the patient's skin while the planning target volume (PTV) was used to devise channels that allow for access and coverage of the tumor bed. An end-to-end dosimetric test was devised to determine feasibility for clinical use. The applicator was designed to conform to the volume and contours inside the orbital cavity. Support wings placed flush with the patient skin provided stability and reproducibility, while 16 source channels of varying length were needed for sufficient access to the target. A solid sheath, printed as an outer support-wall for each channel, prevented bending or accidental puncturing of the surface of the applicator. Quality assurance tests demonstrated feasibility for clinical use. Our experience with available 3D printing technology used to generate an applicator for the orbit may provide guidance for how materials of suitable biomechanical and radiation properties can be used in brachytherapy.
Sections du résumé
BACKGROUND
BACKGROUND
This report describes a process for designing a 3D printed patient-specific applicator for HDR brachytherapy of the orbit.
CASE PRESENTATION
METHODS
A 34-year-old man with recurrent melanoma of the orbit was referred for consideration of re-irradiation. An applicator for HDR brachytherapy was designed based on the computed tomography (CT) of patient anatomy. The body contour was used to generate an applicator with a flush fit against the patient's skin while the planning target volume (PTV) was used to devise channels that allow for access and coverage of the tumor bed. An end-to-end dosimetric test was devised to determine feasibility for clinical use. The applicator was designed to conform to the volume and contours inside the orbital cavity. Support wings placed flush with the patient skin provided stability and reproducibility, while 16 source channels of varying length were needed for sufficient access to the target. A solid sheath, printed as an outer support-wall for each channel, prevented bending or accidental puncturing of the surface of the applicator.
CONCLUSIONS
CONCLUSIONS
Quality assurance tests demonstrated feasibility for clinical use. Our experience with available 3D printing technology used to generate an applicator for the orbit may provide guidance for how materials of suitable biomechanical and radiation properties can be used in brachytherapy.
Identifiants
pubmed: 32601842
doi: 10.1186/s41205-020-00068-3
pii: 10.1186/s41205-020-00068-3
pmc: PMC7322888
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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