Association between a progesterone receptor mutation and hepatitis E sero-positivity in liver transplant recipients.
HEV
PROGINS
cytokines
liver transplant
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
revised:
12
06
2020
received:
13
05
2020
accepted:
25
06
2020
medline:
1
7
2020
pubmed:
1
7
2020
entrez:
1
7
2020
Statut:
ppublish
Résumé
We investigated if the PROGINS mutation increases the risk of hepatitis E virus (HEV) infection in liver transplant recipients. PROGINS was analyzed through KASP assay; HEV serologies assessed via enzyme-linked immunosorbent assay and multiplex cytokine assays were evaluated in plasma with the ProcartaPlex human immunoassay. Seventy liver transplant recipients were evaluated, of which 23 (33%) were HEV immunoglobuln G (IgG)-positive (HEV+). The frequency of PROGINS in the HEV+ group was 34%, compared with 14% in those that were HEV IgG negative (HEV-). Cytokine measurements in a sub-set of samples from HEV+/PROGINS+ individuals showed decreased plasma levels of monokine induced by gamma interferon, a proliferation-inducing ligand, and stem cell factor, as well as increased levels of eotaxin-3 and interleukin-31 compared with those HEV-/PROGINS- samples. Our findings suggest an association between the PROGINS mutation and seropositivity for HEV in liver transplant recipients with consequent distorted cytokine levels.
Identifiants
pubmed: 32603532
doi: 10.1002/jmv.26236
pmc: PMC7772260
mid: NIHMS1620864
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3871-3874Subventions
Organisme : NCI NIH HHS
ID : R21 CA215883
Pays : United States
Organisme : Robert Wood Johnson Foundation
Organisme : American College of Gastroenterology
ID : ACG-CR-033-2016
Informations de copyright
© 2020 Wiley Periodicals LLC.
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