The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
27
03
2020
revised:
04
05
2020
accepted:
11
05
2020
pubmed:
1
7
2020
medline:
1
6
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Candida albicans is a regular member of the intestinal microbiota in the majority of the human population. This underscores C. albicans' adaptation to life in the intestine without inducing competitive interactions with other microbes, or immune responses detrimental to its survival. However, specific conditions such as a dysbalanced microbiome, a suppression of the immune system, and an impaired intestinal barrier can predispose for invasive, mostly nosocomial, C. albicans infections. Colonization of the intestine and translocation through the intestinal barrier are fundamental aspects of the processes preceding life-threatening systemic candidiasis. Insights into C. albicans' commensal lifestyle and translocation can thus help us to understand how patients develop candidiasis, and may provide leads for therapeutic strategies aimed at preventing infection. In this review, we discuss the commensal lifestyle of C. albicans in the intestine, the role of morphology for commensalism, the influence of diet, and the interactions with bacteria of the microbiota.
Identifiants
pubmed: 32604030
pii: S1369-5274(20)30066-7
doi: 10.1016/j.mib.2020.05.006
pmc: PMC7744392
mid: NIHMS1600173
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-15Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI118898
Pays : United States
Organisme : Wellcome Trust
ID : 215599/Z/19/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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