Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.
HIV treat all
HIV/AIDS
advanced HIV
antiretroviral therapy
cryptococcal antigen
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
04 05 2021
04 05 2021
Historique:
received:
20
04
2020
accepted:
24
06
2020
pubmed:
1
7
2020
medline:
21
5
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.
Identifiants
pubmed: 32604411
pii: 5865448
doi: 10.1093/cid/ciaa899
pmc: PMC8096249
doi:
Substances chimiques
Antigens, Fungal
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1635-1638Subventions
Organisme : NIAID NIH HHS
ID : F32 AI140511
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007044
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Références
J Infect Dis. 2019 Feb 23;219(6):877-883
pubmed: 30325463
Clin Infect Dis. 2009 Apr 1;48(7):856-62
pubmed: 19222372
Clin Infect Dis. 2019 Feb 1;68(4):688-698
pubmed: 30020446
Clin Infect Dis. 2018 Mar 4;66(suppl_2):S152-S159
pubmed: 29514236
Lancet. 2015 May 30;385(9983):2173-82
pubmed: 25765698
Lancet Infect Dis. 2017 Aug;17(8):873-881
pubmed: 28483415
Clin Infect Dis. 2020 Apr 01;:
pubmed: 32236414
Clin Infect Dis. 2018 Feb 10;66(5):686-692
pubmed: 29028998
Neurology. 2015 May 12;84(19):1988-90
pubmed: 25964478