The Value of Laboratory Parameters for Anemia, Renal Function, Systemic Inflammation and Nutritional Status as Predictors for Outcome in Elderly Patients with Head-and-Neck Cancers.
C-reactive protein
albumin
chemotherapy
elderly patients
head-and-neck cancer
head-and-neck squamous cell carcinoma
radiotherapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Jun 2020
26 Jun 2020
Historique:
received:
24
04
2020
revised:
05
06
2020
accepted:
23
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
The purpose of this study was to evaluate the value of routine blood markers regarding their predictive potential for treatment outcomes of elderly head-and-neck squamous cell carcinoma (HNSCC) patients. In total, 246 elderly HNSCC patients (≥65 years) undergoing (chemo)radiotherapy from 2010 to 2018 were analyzed for treatment outcomes, depending on their hemoglobin, glomerular filtration rate (GFR), C-reactive protein (CRP) and albumin values, representing anemia, kidney function, inflammation and nutrition status, respectively. Local/locoregional control, progression-free and overall survival (OS) were calculated using the Kaplan-Meier method. Cox analyses were performed to examine the influence of blood parameters on oncological outcomes. In the univariate Cox regression analysis, hemoglobin ≤ 12 g/dL (HR = 1.536,
Identifiants
pubmed: 32604773
pii: cancers12061698
doi: 10.3390/cancers12061698
pmc: PMC7352755
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Laryngoscope. 2017 Dec;127(12):E437-E442
pubmed: 28561532
Int J Mol Sci. 2019 Sep 27;20(19):
pubmed: 31569614
Oncoimmunology. 2020 Feb 26;9(1):1731942
pubmed: 32158624
PLoS One. 2013;8(1):e55327
pubmed: 23383155
Acta Oncol. 2011 Oct;50(7):1006-14
pubmed: 21790306
J Laryngol Otol. 2016 May;130(S2):S32-S40
pubmed: 27841109
Sci Rep. 2017 Dec 19;7(1):17805
pubmed: 29259311
Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):459-66
pubmed: 10661354
Lancet. 2006 Sep 2;368(9538):843-54
pubmed: 16950362
Ann Intern Med. 2009 Oct 6;151(7):483-95
pubmed: 19805771
Br J Cancer. 2006 Aug 21;95(4):431-4
pubmed: 16880793
Cancers (Basel). 2020 Mar 08;12(3):
pubmed: 32182693
Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1121-7
pubmed: 9194763
Am J Hematol. 2014 Jan;89(1):88-96
pubmed: 24122955
J Clin Oncol. 2009 Jun 10;27(17):2758-65
pubmed: 19403886
Arch Otolaryngol Head Neck Surg. 2001 Sep;127(9):1089-92
pubmed: 11556858
Radiat Oncol. 2020 Feb 4;15(1):31
pubmed: 32019576
Cureus. 2019 May 12;11(5):e4648
pubmed: 31312573
Br J Nutr. 2011 Sep;106(5):708-17
pubmed: 21450117
Am J Clin Oncol. 2006 Apr;29(2):183-8
pubmed: 16601440
Eur J Nucl Med Mol Imaging. 2020 May;47(5):1046-1055
pubmed: 31811344
Eur Arch Otorhinolaryngol. 2019 May;276(5):1475-1486
pubmed: 30830300
Rep Pract Oncol Radiother. 2015 Jul-Aug;20(4):249-58
pubmed: 26109912
BMC Cancer. 2020 Feb 22;20(1):146
pubmed: 32087695
Lancet Oncol. 2010 Jan;11(1):21-8
pubmed: 19897418
Nutr Cancer. 2001;39(2):210-3
pubmed: 11759282
Laryngoscope. 2018 Apr;128(4):831-840
pubmed: 28833217
Eur Arch Otorhinolaryngol. 2010 Oct;267(10):1619-21
pubmed: 20454970
Oral Maxillofac Surg Clin North Am. 2014 May;26(2):123-41
pubmed: 24794262
Lancet. 2003 Oct 18;362(9392):1255-60
pubmed: 14575968
BMC Cancer. 2017 Apr 21;17(1):285
pubmed: 28431566
Cancer Med. 2019 Dec;8(17):7454-7468
pubmed: 31599129
Radiology. 1996 Nov;201(2):553-8
pubmed: 8888257
J Natl Cancer Inst. 1994 Dec 7;86(23):1766-70
pubmed: 7966414
Laryngoscope. 2016 Jul;126(7):1567-71
pubmed: 26864349
Arch Intern Med. 2005 Oct 24;165(19):2214-20
pubmed: 16246985
Br J Cancer. 2015 Jun 30;113(1):76-82
pubmed: 26057452
Clin Nutr. 2013 Dec;32(6):1007-11
pubmed: 23755842
Mol Cancer Res. 2011 Dec;9(12):1658-67
pubmed: 21976712
N Engl J Med. 2004 May 6;350(19):1937-44
pubmed: 15128893
Aging Clin Exp Res. 2019 Jun;31(6):793-798
pubmed: 31148100
Radiat Oncol. 2020 Apr 16;15(1):81
pubmed: 32299456
J Clin Oncol. 2003 Jan 1;21(1):92-8
pubmed: 12506176
Semin Hematol. 2008 Oct;45(4):210-7
pubmed: 18809090
Radiother Oncol. 2015 Oct;117(1):113-7
pubmed: 26432067
Int J Radiat Oncol Biol Phys. 2003 Jul 1;56(3):778-87
pubmed: 12788185
Crit Rev Clin Lab Sci. 2011 Jul-Aug;48(4):155-70
pubmed: 22035340
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
J Clin Oncol. 2009 Dec 20;27(36):6199-206
pubmed: 19917835
N Engl J Med. 2004 May 6;350(19):1945-52
pubmed: 15128894
N Engl J Med. 1993 Sep 30;329(14):987-94
pubmed: 8141877
N Engl J Med. 2006 Feb 9;354(6):567-78
pubmed: 16467544
Radiother Oncol. 2009 Jul;92(1):4-14
pubmed: 19446902
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1008-17
pubmed: 17716826
Rep Pract Oncol Radiother. 2012 Aug 10;18(1):16-25
pubmed: 24381743