Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus-One of Several Possible Reasons for an Increased Cardiovascular Risk.
BMI
bioinformatics
cardiovascular risk
children
echocardiography
gestational diabetes mellitus
miRWalk2.0 database
microRNA expression
prehypertension/hypertension
screening
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
16
04
2020
revised:
19
06
2020
accepted:
25
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Gestational diabetes mellitus (GDM), one of the major pregnancy-related complications, characterized as a transitory form of diabetes induced by insulin resistance accompanied by a low/absent pancreatic beta-cell compensatory adaptation to the increased insulin demand, causes the acute, long-term, and transgenerational health complications. The aim of the study was to assess if alterations in gene expression of microRNAs associated with diabetes/cardiovascular/cerebrovascular diseases are present in whole peripheral blood of children aged 3-11 years descending from GDM complicated pregnancies. A substantially altered microRNA expression profile was found in children descending from GDM complicated pregnancies. Almost all microRNAs with the exception of miR-92a-3p, miR-155-5p, and miR-210-3p were upregulated. The microRNA expression profile also differed between children after normal and GDM complicated pregnancies in relation to the presence of overweight/obesity, prehypertension/hypertension, and/or valve problems and heart defects. Always, screening based on the combination of microRNAs was superior over using individual microRNAs, since at 10.0% false positive rate it was able to identify a large proportion of children with an aberrant microRNA expression profile (88.14% regardless of clinical findings, 75.41% with normal clinical findings, and 96.49% with abnormal clinical findings). In addition, the higher incidence of valve problems and heart defects was found in children with a prior exposure to GDM. The extensive file of predicted targets of all microRNAs aberrantly expressed in children descending from GDM complicated pregnancies indicates that a large group of these genes is involved in ontologies of diabetes/cardiovascular/cerebrovascular diseases. In general, children with a prior exposure to GDM are at higher risk of later development of diabetes mellitus and cardiovascular/cerebrovascular diseases, and would benefit from dispensarisation as well as implementation of primary prevention strategies.
Identifiants
pubmed: 32604801
pii: cells9061557
doi: 10.3390/cells9061557
pmc: PMC7349356
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
J Mol Cell Cardiol. 2017 May;106:55-67
pubmed: 28342976
J Mol Cell Cardiol. 2019 Apr;129:281-292
pubmed: 30878395
EBioMedicine. 2019 Nov;49:341-353
pubmed: 31636010
Evid Based Complement Alternat Med. 2013;2013:510208
pubmed: 23762142
Nucleic Acids Res. 2013 Apr;41(8):4470-80
pubmed: 23470996
Pediatr Res. 2013 Sep;74(3):272-8
pubmed: 23783433
J Nephrol. 2018 Dec;31(6):813-831
pubmed: 30019103
J Mol Cell Cardiol. 2015 Apr;81:1-9
pubmed: 25633833
Chest. 2016 Mar;149(3):786-800
pubmed: 26270249
Respir Res. 2018 Oct 2;19(1):194
pubmed: 30285853
Leukemia. 2012 Sep;26(9):2011-8
pubmed: 22456625
Vascul Pharmacol. 2019 May;116:24-35
pubmed: 28694128
J Pediatr. 2020 Apr;219:173-179.e1
pubmed: 31987655
Br J Pharmacol. 2019 Jul;176(13):2179-2194
pubmed: 30883703
Diabetologia. 2018 May;61(5):1037-1045
pubmed: 29492638
Mol Cell Endocrinol. 2019 Jun 15;490:1-14
pubmed: 30926524
Curr Biol. 2010 Feb 9;20(3):265-70
pubmed: 20116252
Cardiovasc Res. 2013 Mar 1;97(3):432-42
pubmed: 23208587
J Am Soc Hypertens. 2017 Dec;11(12):831-841.e4
pubmed: 29146158
Genet Test Mol Biomarkers. 2018 Nov;22(11):644-651
pubmed: 30346833
Cell Death Differ. 2013 Dec;20(12):1603-14
pubmed: 24212931
Gene. 2016 May 10;582(1):14-8
pubmed: 26826461
Stroke. 2017 Jan;48(1):10-16
pubmed: 27899750
Cell Death Dis. 2017 Jan 19;8(1):e2559
pubmed: 28102847
PLoS One. 2011;6(8):e23925
pubmed: 21887347
PLoS One. 2016 Nov 15;11(11):e0166688
pubmed: 27846323
Diabetes Res Clin Pract. 2018 Jul;141:35-46
pubmed: 29679626
J Obstet Gynaecol Res. 2017 Jun;43(6):974-981
pubmed: 28621051
J Clin Invest. 2007 Sep;117(9):2369-76
pubmed: 17786230
Nat Rev Genet. 2002 Sep;3(9):662-73
pubmed: 12209141
Circ Res. 2019 Feb 15;124(4):575-587
pubmed: 30582459
Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
pubmed: 12184808
J Med Biochem. 2018 Dec 01;37(4):499-506
pubmed: 30584410
Cell Physiol Biochem. 2015;35(6):2285-98
pubmed: 25895816
Mol Med Rep. 2014 Jun;9(6):2528-32
pubmed: 24682318
BMC Genomics. 2012 Oct 15;13:552
pubmed: 23066896
Eur J Cardiothorac Surg. 2016 Jun;49(6):1725-31
pubmed: 26802145
Ann Transl Med. 2016 Dec;4(24):539
pubmed: 28149900
Biosci Biotechnol Biochem. 2019 Sep;83(9):1655-1662
pubmed: 31272285
Diabetologia. 2018 May;61(5):1124-1134
pubmed: 29445851
Biomarkers. 2020 Feb;25(1):40-47
pubmed: 31694408
PLoS One. 2018 Jan 12;13(1):e0190676
pubmed: 29329330
J Clin Med. 2019 May 30;8(6):
pubmed: 31151180
Sci Rep. 2018 Jan 15;8(1):724
pubmed: 29335596
Diabetes. 2017 Dec;66(12):3072-3084
pubmed: 28970282
Life Sci. 2019 May 1;224:67-75
pubmed: 30684546
PLoS One. 2011;6(5):e20038
pubmed: 21625387
Pediatr Res. 2018 Apr;83(4):866-873
pubmed: 29281614
Sci Rep. 2016 Nov 23;6:36904
pubmed: 27876829
J Clin Med. 2019 Oct 03;8(10):
pubmed: 31623405
PLoS One. 2015 May 28;10(5):e0128372
pubmed: 26020947
World Neurosurg. 2019 Nov;131:e486-e494
pubmed: 31382062
Arch Pediatr Adolesc Med. 2012 Apr;166(4):337-43
pubmed: 22213602
Genet Mol Res. 2015 Dec 01;14(4):15462-70
pubmed: 26634512
Reproduction. 2016 Dec;152(6):R211-R222
pubmed: 27601712
Biochem Biophys Res Commun. 2018 Sep 3;503(1):71-78
pubmed: 29852165
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13699-704
pubmed: 26483456
Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76
pubmed: 15286277
Metabolism. 2015 Sep;64(9):1051-9
pubmed: 26031505
PLoS One. 2015 Jun 16;10(6):e0127175
pubmed: 26079930
Mol Biol (Mosk). 2017 Jul-Aug;51(4):683-695
pubmed: 28900088
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18255-60
pubmed: 17108080
Int J Mol Sci. 2019 Feb 02;20(3):
pubmed: 30717412
J Cell Mol Med. 2020 Jan;24(1):1146-1150
pubmed: 31709737
BMC Res Notes. 2013 Nov 26;6:491
pubmed: 24279768
J Clin Endocrinol Metab. 2012 Jul;97(7):E1213-8
pubmed: 22535975
Med Sci Monit. 2016 Jun 24;22:2175-81
pubmed: 27341015
Cardiol J. 2016;23(5):556-562
pubmed: 27515482
Oncol Lett. 2011 Nov;2(6):1019-1023
pubmed: 22848262
Front Mol Neurosci. 2017 Nov 21;10:383
pubmed: 29209166
Nature. 2011 Jun 08;474(7353):649-53
pubmed: 21654750
Diabetes Care. 2004 Jan;27 Suppl 1:S88-90
pubmed: 14693936
Diabetes. 2019 Mar;68(3):515-526
pubmed: 30552111
Am J Cardiovasc Dis. 2018 Feb 05;8(1):1-13
pubmed: 29531852
J Cell Biochem. 2020 Feb;121(2):996-1004
pubmed: 31452254
J Cell Biochem. 2019 Apr;120(4):6304-6314
pubmed: 30362166
J Biomed Inform. 2011 Oct;44(5):839-47
pubmed: 21605702
Life Sci. 2016 Feb 15;147:117-24
pubmed: 26827991
Circ Res. 2014 Oct 24;115(10):857-66
pubmed: 25201911
Pediatr Crit Care Med. 2020 Apr;21(4):340-349
pubmed: 31876555
Clin Sci (Lond). 2016 Nov 1;130(21):1955-67
pubmed: 27562513
Eur J Endocrinol. 2019 Nov;181(5):565-577
pubmed: 31539877
Gene. 2018 Sep 25;672:137-142
pubmed: 29879500
Mol Psychiatry. 2019 Apr;24(4):536-548
pubmed: 29520039
Cell Biol Int. 2018 Nov;42(11):1584-1593
pubmed: 30203887
Sci Rep. 2018 Apr 27;8(1):6699
pubmed: 29703907
Ann Thorac Surg. 2016 Oct;102(4):1245-52
pubmed: 27234576
J Transl Med. 2019 Jul 22;17(1):232
pubmed: 31331347
Pediatr Res. 2007 May;61(5 Pt 2):17R-23R
pubmed: 17413846
Oncotarget. 2017 Aug 24;8(53):91362-91378
pubmed: 29207650
Appl Biochem Biotechnol. 2018 Sep;186(1):245-255
pubmed: 29574510
Diabetes. 2018 May;67(5):1013-1023
pubmed: 29453204
Mol Pharmacol. 2011 Oct;80(4):558-64
pubmed: 21737570
Front Endocrinol (Lausanne). 2017 Dec 12;8:345
pubmed: 29312141
Clinics (Sao Paulo). 2013 Jan;68(1):75-80
pubmed: 23420161
BMC Med Genomics. 2013 Sep 30;6:36
pubmed: 24079748
Kardiol Pol. 2018;76(2):362-369
pubmed: 29350392
Int J Mol Sci. 2020 Jan 09;21(2):
pubmed: 31936594
EMBO Mol Med. 2018 Mar;10(3):
pubmed: 29374012
J Mol Cell Cardiol. 2018 Jan;114:72-82
pubmed: 29122578
Acta Diabetol. 2018 Oct;55(10):1037-1042
pubmed: 29936651
Eur J Heart Fail. 2016 Aug;18(8):1000-8
pubmed: 27072074
Cardiorenal Med. 2012 May;2(2):134-142
pubmed: 22851962
Mol Med Rep. 2018 Jan;17(1):1469-1484
pubmed: 29138825
Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2223-2233
pubmed: 30915770
J Transl Med. 2015 Sep 24;13:314
pubmed: 26404540
Oncotarget. 2016 Jun 14;7(24):36614-36621
pubmed: 27191494
FEBS Open Bio. 2017 Feb 20;7(4):504-521
pubmed: 28396836
Crit Rev Toxicol. 2012 Nov;42(10):877-89
pubmed: 22989067
Hypertension. 2018 Feb;71(2):280-288
pubmed: 29255073
Mol Metab. 2019 Feb;20:63-78
pubmed: 30503831
Diabetes. 2006 Feb;55(2):460-5
pubmed: 16443781
Diabetol Metab Syndr. 2016 Jan 15;8:6
pubmed: 26779287
Sci Rep. 2018 Jan 22;8(1):1366
pubmed: 29358694
Front Genet. 2011 Nov 22;2:84
pubmed: 22303378
Diabetes Care. 2010 Mar;33(3):676-82
pubmed: 20190296
J Autism Dev Disord. 2014 Apr;44(4):766-75
pubmed: 24057131
Circ Res. 2015 Oct 23;117(10):870-883
pubmed: 26311719
Hypertension. 2015 Oct;66(4):793-9
pubmed: 26283043
Genetics. 2015 Apr;199(4):887-96
pubmed: 25855649
Noncoding RNA. 2018 Nov 21;4(4):
pubmed: 30469437
Atherosclerosis. 2019 Mar;282:121-131
pubmed: 30731284
Thromb Haemost. 2017 May 3;117(5):992-1001
pubmed: 28251236
Mol Med Rep. 2017 Nov;16(5):7766-7774
pubmed: 28944900
Am J Hypertens. 2009 Feb;22(2):215-20
pubmed: 19023272
Nucleic Acid Ther. 2013 Oct;23(5):344-54
pubmed: 23988020
Cell Physiol Biochem. 2018;51(1):46-62
pubmed: 30439713
J Cell Biochem. 2019 Mar;120(3):4451-4462
pubmed: 30302809
Sci Rep. 2018 Feb 1;8(1):2104
pubmed: 29391491
Genes Immun. 2014 Jan;15(1):57-61
pubmed: 24285176
Eur Heart J. 2014 Dec 1;35(45):3203-11
pubmed: 22450430
Mol Med Rep. 2016 Jul;14(1):184-94
pubmed: 27176713
BMJ. 2019 Dec 4;367:l6398
pubmed: 31801789
Genomics. 2020 Jan;112(1):669-676
pubmed: 31029863
Int J Endocrinol Metab. 2019 May 14;17(3):e86640
pubmed: 31497041
Transl Stroke Res. 2014 Dec;5(6):711-8
pubmed: 25127724
BMC Biol. 2015 Jan 31;13:7
pubmed: 25637097
Curr Diab Rep. 2019 Nov 21;19(12):143
pubmed: 31754898
Exp Diabetes Res. 2011;2011:906154
pubmed: 21804818
Exp Ther Med. 2018 Aug;16(2):595-602
pubmed: 30116316
Endocr Connect. 2017 Nov;6(8):773-790
pubmed: 28986402
Arch Dis Child Fetal Neonatal Ed. 1999 Jul;81(1):F10-4
pubmed: 10375355
J Biochem Mol Toxicol. 2011 Nov-Dec;25(6):404-8
pubmed: 22190509
Front Mol Neurosci. 2018 Sep 28;11:292
pubmed: 30323739
Am J Obstet Gynecol. 2016 Sep;215(3):380.e1-7
pubmed: 27018463
EBioMedicine. 2018 May;31:143-149
pubmed: 29709497
Cell Physiol Biochem. 2018;45(1):226-236
pubmed: 29357324
Biochimie. 2019 Jul;162:1-7
pubmed: 30922869
J Mol Biomark Diagn. 2015 Nov;6(6):
pubmed: 27308097
Diabetes Res Clin Pract. 2007 Nov;78(2):238-45
pubmed: 17499877
Biochem Soc Trans. 2013 Jun;41(3):803-7
pubmed: 23697941
Int J Mol Sci. 2018 Sep 26;19(10):
pubmed: 30261627
J Mol Cell Cardiol. 2016 Aug;97:162-8
pubmed: 27192016
Braz J Med Biol Res. 2020 Jan 24;53(2):e9106
pubmed: 31994603
Int J Clin Exp Pathol. 2014 Jan 15;7(2):565-74
pubmed: 24551276
PLoS One. 2019 Aug 8;14(8):e0219261
pubmed: 31393881
Diabetes Care. 2009 Jan;32 Suppl 1:S62-7
pubmed: 19118289
PLoS One. 2018 Oct 17;13(10):e0204235
pubmed: 30332417
Oncotarget. 2017 Jul 18;8(29):48145-48156
pubmed: 28624816
Cell Physiol Biochem. 2016;40(6):1591-1602
pubmed: 27997916
Nat Struct Mol Biol. 2008 Mar;15(3):259-67
pubmed: 18311153
Circ Res. 2009 Jan 30;104(2):170-8, 6p following 178
pubmed: 19096030
Mol Ther Nucleic Acids. 2019 Dec 6;18:954-965
pubmed: 31770672
Sci Rep. 2015 Nov 05;5:16099
pubmed: 26537670
Oxid Med Cell Longev. 2018 Dec 2;2018:7042105
pubmed: 30622671
PLoS One. 2014 Nov 19;9(11):e113752
pubmed: 25409512
Endocrine. 2019 Nov;66(2):226-239
pubmed: 31559537
Curr Opin Behav Sci. 2017 Apr;14:140-147
pubmed: 29270445
Noncoding RNA. 2018 Nov 27;4(4):
pubmed: 30486455
Mol Cells. 2017 Aug;40(8):542-549
pubmed: 28756653
J Physiol Biochem. 2019 Feb;75(1):73-81
pubmed: 30426460
Am J Hypertens. 2019 Mar 16;32(4):335-342
pubmed: 30624576
Am J Epidemiol. 2013 Oct 15;178(8):1219-25
pubmed: 23956097
Cardiovasc Res. 2010 Aug 1;87(3):535-44
pubmed: 20164119
J Matern Fetal Neonatal Med. 2019 Aug;32(15):2529-2538
pubmed: 29429374
FASEB J. 2013 Apr;27(4):1460-7
pubmed: 23271053
J Cell Mol Med. 2019 Sep 30;:
pubmed: 31568645
Diabetes Care. 1998 Aug;21 Suppl 2:B161-7
pubmed: 9704245
Circulation. 2018 Nov 27;138(22):2545-2558
pubmed: 30571345
J Heart Valve Dis. 2016 Sep;25(5):580-588
pubmed: 28238240
Rheumatol Int. 2018 Jul;38(7):1199-1205
pubmed: 29845432
J Clin Endocrinol Metab. 2018 Apr 1;103(4):1447-1458
pubmed: 29409019
Diabetes Care. 2018 Dec;41(12):2502-2508
pubmed: 30373735
Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E836-43
pubmed: 23443922
Curr Diab Rep. 2017 May;17(5):35
pubmed: 28378294
Cold Spring Harb Perspect Biol. 2016 Feb 01;8(2):a019497
pubmed: 26834142
Pediatr Obes. 2020 May;15(5):e12611
pubmed: 31920001
Biosci Biotechnol Biochem. 2020 Feb;84(2):321-329
pubmed: 31680642
Brain Res. 2012 Mar 20;1444:96-111
pubmed: 22330722
Diabetes Care. 2008 Feb;31(2):340-6
pubmed: 18000174
Acta Diabetol. 2011 Mar;48(1):61-9
pubmed: 20857148
Sci Rep. 2017 Aug 1;7(1):6998
pubmed: 28765595
Biomed Res Int. 2014;2014:418628
pubmed: 24900964
Neurosci Biobehav Rev. 2012 Jan;36(1):79-89
pubmed: 21565217
Int J Cardiol. 2015 Oct 15;197:123-4
pubmed: 26134369
Cell Physiol Biochem. 2017;44(3):884-896
pubmed: 29176317
Cardiol Res Pract. 2019 Nov 29;2019:8645840
pubmed: 31885906
Am J Transl Res. 2019 Jun 15;11(6):3610-3619
pubmed: 31312371
Diabetes Care. 2019 Mar;42(3):372-380
pubmed: 30655380
Small. 2020 Jan;16(3):e1904044
pubmed: 31867895
Diabetes Metab Res Rev. 2003 Jul-Aug;19(4):259-70
pubmed: 12879403
J Cell Physiol. 2019 Mar 18;:
pubmed: 30883744
Physiol Genomics. 2017 Apr 1;49(4):243-252
pubmed: 28213571
Biochem Biophys Res Commun. 2018 Jun 27;501(3):688-695
pubmed: 29758198
Int J Cardiol. 2016 Dec 1;224:231-239
pubmed: 27661412
Curr Biol. 2010 Feb 9;20(3):271-7
pubmed: 20116247
Int J Gynaecol Obstet. 2015 Jul;130(1):49-53
pubmed: 25887942
Circ Res. 2007 Apr 27;100(8):1164-73
pubmed: 17379831
Cardiovasc Ther. 2016 Aug;34(4):199-208
pubmed: 27085964
Eur J Heart Fail. 2013 Jun;15(6):650-9
pubmed: 23388090
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
BMC Pregnancy Childbirth. 2018 Dec 14;18(1):495
pubmed: 30547777
Neurochem Int. 2017 Jul;107:156-167
pubmed: 28202285
Diabetes Care. 2017 May;40(5):679-686
pubmed: 28279981
Circ Res. 2017 Sep 29;121(8):970-980
pubmed: 28724745
Int J Cardiol. 2016 Dec 1;224:310-316
pubmed: 27665403
Cell Physiol Biochem. 2014;34(3):955-65
pubmed: 25200830
Trends Cardiovasc Med. 2014 Apr;24(3):105-12
pubmed: 24183793
Neurosci Res. 2018 May;130:8-22
pubmed: 28803788
Cell Immunol. 2010;260(2):70-4
pubmed: 19954774
Korean J Physiol Pharmacol. 2014 Oct;18(5):359-63
pubmed: 25352753
Oncotarget. 2018 Jul 17;9(55):30485-30498
pubmed: 30093963
Atherosclerosis. 2019 Oct;289:1-7
pubmed: 31437610
Curr Opin Endocrinol Diabetes Obes. 2010 Dec;17(6):493-9
pubmed: 20962634
Hum Mol Genet. 2018 May 15;27(10):1763-1771
pubmed: 29528396
Int J Clin Exp Med. 2015 Nov 15;8(11):21071-9
pubmed: 26885038
Biochem Biophys Res Commun. 2016 May 13;473(4):859-866
pubmed: 27038547
Mol Diagn Ther. 2018 Jun;22(3):345-352
pubmed: 29556924
Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E262-E275
pubmed: 31821038
J Am Heart Assoc. 2014 Sep 23;3(5):e000972
pubmed: 25249297
EXCLI J. 2017 Dec 12;16:1297-1307
pubmed: 29333131
JAMA. 2015 Apr 14;313(14):1425-34
pubmed: 25871668
Curr Neurovasc Res. 2020;17(1):11-17
pubmed: 31870262
Mol Cell Biochem. 2017 Jul;431(1-2):123-131
pubmed: 28281187
J Clin Lab Anal. 2016 Sep;30(5):727-31
pubmed: 26892629
Cardiology. 2009;113(2):81-8
pubmed: 19018142
Diabetologia. 1996 Aug;39(8):976-83
pubmed: 8858221
Biomed Pharmacother. 2016 Oct;83:92-99
pubmed: 27470555
Oncotarget. 2015 Nov 3;6(34):35372-82
pubmed: 26498351
Mol Cell Biochem. 2017 Mar;427(1-2):187-199
pubmed: 28000044
Biochemistry (Mosc). 2014 Jun;79(6):538-44
pubmed: 25100012
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
pubmed: 16885212
Adv Genet. 2010;71:3-39
pubmed: 20933124
Diabetes Care. 2007 Jul;30 Suppl 2:S112-9
pubmed: 17596458
Diabetes Res Clin Pract. 2017 Oct;132:1-9
pubmed: 28783527
J Cell Mol Med. 2018 Nov;22(11):5698-5707
pubmed: 30589501
Cell. 2008 Apr 18;133(2):217-22
pubmed: 18423194
Acta Diabetol. 2019 Jan;56(1):55-65
pubmed: 30167868
J Mol Med (Berl). 2018 Aug;96(8):845-856
pubmed: 30008018
Gene. 2016 Oct 10;591(1):90-96
pubmed: 27374153
Oxid Med Cell Longev. 2019 Dec 13;2019:9567641
pubmed: 31915515
Sci Rep. 2016 Mar 08;6:22862
pubmed: 26953132
Int J Mol Sci. 2020 Jan 11;21(2):
pubmed: 31940853
Pregnancy Hypertens. 2019 Jul;17:5-11
pubmed: 31487656