Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation.
Box–Behnken
biodegradable polymers
clinical pharmacokinetics
drug delivery
nanoparticles
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
26 Jun 2020
26 Jun 2020
Historique:
received:
06
06
2020
revised:
22
06
2020
accepted:
23
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
Avanafil (AVA) is a second-generation phosphodiesterase-5 (PDE5) inhibitor. AVA shows high selectivity to penile tissues and fast absorption, but has a bioavailability of about 36%. The aim was to formulate and optimize AVA-biodegradable nanoparticles (NPs) to enhance AVA bioavailability. To assess the impact of variables, the Box-Behnken design was utilized to investigate and optimize the formulation process variables: the AVA:poly (lactic-co-glycolic acid) (PLGA) ratio (
Identifiants
pubmed: 32604853
pii: pharmaceutics12060596
doi: 10.3390/pharmaceutics12060596
pmc: PMC7356025
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : King Abdulaziz University
ID : G-222-249-1440
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