Naringenin-Functionalized Multi-Walled Carbon Nanotubes: A Potential Approach for Site-Specific Remote-Controlled Anticancer Delivery for the Treatment of Lung Cancer Cells.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Jun 2020
Historique:
received: 08 05 2020
revised: 23 06 2020
accepted: 24 06 2020
entrez: 2 7 2020
pubmed: 2 7 2020
medline: 23 3 2021
Statut: epublish

Résumé

Multi-walled carbon nanotubes functionalized with naringenin have been developed as new drug carriers to improve the performance of lung cancer treatment. The nanocarrier was characterized by Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), X-ray photoelectron spectroscopy, Raman Spectroscopy, and Differential Scanning Calorimetry (DSC). Drug release rates were determined in vitro by the dialysis method. The cytotoxic profile was evaluated using the MTT assay, against a human skin

Identifiants

pubmed: 32604979
pii: ijms21124557
doi: 10.3390/ijms21124557
pmc: PMC7348916
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Drug Carriers 0
Flavanones 0
Nanotubes, Carbon 0
naringenin HN5425SBF2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Banco do Nordeste
ID : grant FUNDECI/2016.0015
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe (Fapitec) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
ID : CNPq, FAPITEC, CAPES
Organisme : Portuguese Science and Technology Foundation
ID : M-ERA-NET/0004/2015-PAIRED and UIDB/04469/2020 (strategic fund)

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Auteurs

Renata P Morais (RP)

Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.

Gabrielle B Novais (GB)

Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.

Leandro S Sangenito (LS)

Federal University of Rio de Janeiro (UFRJ), 373, Carlos Chagas Filho Ave, Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.

André L S Santos (ALS)

Federal University of Rio de Janeiro (UFRJ), 373, Carlos Chagas Filho Ave, Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.

Ronny Priefer (R)

School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Avenue, Boston, MA 02115, USA.

Margreet Morsink (M)

Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
Translational Liver Research, Department of Medical Cell BioPhysics, Technical Medical Centre, Faculty of Science and Technology, University of Twente, 7522 NB Enschede, The Netherlands.
Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, 7522 NB Enschede, The Netherlands.

Marcelo C Mendonça (MC)

Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.

Eliana B Souto (EB)

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

Patrícia Severino (P)

Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Tiradentes Institute, 150 Mt Vernon St, Dorchester, MA 02125, USA.

Juliana C Cardoso (JC)

Tiradentes University (UNIT), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.
Technology and Research Institute (ITP), 300, Murilo Dantas Ave, Farolândia 49032-490, Brazil.

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Classifications MeSH