Manno-

Cyclohexanols / chemical synthesis Drug Discovery Enzyme Inhibitors / chemical synthesis Humans Mannosidases / antagonists & inhibitors Molecular Structure

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
29 07 2020
Historique:
pubmed: 2 7 2020
medline: 16 4 2021
entrez: 2 7 2020
Statut: ppublish

Résumé

Golgi mannosidase II (GMII) catalyzes the sequential hydrolysis of two mannosyl residues from GlcNAcMan

Identifiants

DOI: 10.1021/jacs.0c03880 PMID: 32605368
pubmed: 32605368
doi: 10.1021/jacs.0c03880
doi:

Substances chimiques

Cyclohexanols 0
Enzyme Inhibitors 0
cyclophellitol 126661-83-4
Mannosidases EC 3.2.1.-
mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase EC 3.2.1.114

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13021-13029

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R001162/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011151/1
Pays : United Kingdom

Auteurs

Zachary Armstrong (Z)

Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, United Kingdom.
ORCID: 0000-0002-4086-2946

Chi-Lin Kuo (CL)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
ORCID: 0000-0003-3748-5008

Daniël Lahav (D)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Bing Liu (B)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Rachel Johnson (R)

Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, United Kingdom.

Thomas J M Beenakker (TJM)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Casper de Boer (C)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
ORCID: 0000-0002-0869-6060

Chung-Sing Wong (CS)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Erwin R van Rijssel (ER)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Marjoke F Debets (MF)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Bogdan I Florea (BI)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
ORCID: 0000-0001-7114-2266

Colin Hissink (C)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Rolf G Boot (RG)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Paul P Geurink (PP)

Oncode Institute & Department of Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
ORCID: 0000-0003-1849-1111

Huib Ovaa (H)

Oncode Institute & Department of Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
ORCID: 0000-0002-0068-054X

Mario van der Stelt (M)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
ORCID: 0000-0002-1029-5717

Gijsbert M van der Marel (GM)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
ORCID: 0000-0003-3531-2138

Jeroen D C Codée (JDC)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Johannes M F G Aerts (JMFG)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Liang Wu (L)

Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, United Kingdom.
ORCID: 0000-0003-0294-7065

Herman S Overkleeft (HS)

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
ORCID: 0000-0001-6976-7005

Gideon J Davies (GJ)

Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, United Kingdom.
ORCID: 0000-0002-7343-776X

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Classifications MeSH

questionsmedicales.fr › Lipides › Alcools gras › Hexanols › Cyclohexanols › Manno-
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Manno-
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Manno-
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Manno-
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Mannosidases › Manno-
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Manno-