Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition.

Apoptosis Gene Expression Regulation, Leukemic / genetics Histone Demethylases / antagonists & inhibitors Humans Leukemia / physiopathology Transcription Factors

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
10 2020
Historique:
received: 13 12 2019
revised: 09 05 2020
accepted: 25 06 2020
pubmed: 2 7 2020
medline: 20 11 2021
entrez: 2 7 2020
Statut: ppublish

Résumé

The cell of origin of oncogenic transformation is a determinant of therapeutic sensitivity, but the mechanisms governing cell-of-origin-driven differences in therapeutic response have not been delineated. Leukemias initiating in hematopoietic stem cells (HSC) are less sensitive to chemotherapy and highly express the transcription factor

Identifiants

DOI: 10.1158/2159-8290.CD-19-1469 PMID: 32606137 PMC: PMC7584353
pubmed: 32606137
pii: 2159-8290.CD-19-1469
doi: 10.1158/2159-8290.CD-19-1469
pmc: PMC7584353
mid: NIHMS1608900
doi:

Substances chimiques

Transcription Factors 0
Histone Demethylases EC 1.14.11.-
KDM1A protein, human EC 1.5.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1500-1513

Subventions

Organisme : NCI NIH HHS
ID : P01 CA108671
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA140575
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA066996
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197594
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA013106
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2020 American Association for Cancer Research.

Références

Cell Rep. 2018 Mar 27;22(13):3641-3659
pubmed: 29590629
Cancer Cell. 2011 Jul 12;20(1):66-78
pubmed: 21741597
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
J Exp Med. 2011 Nov 21;208(12):2403-16
pubmed: 22084405
Blood. 2012 Jun 14;119(24):5838-49
pubmed: 22553314
J Clin Invest. 2016 Oct 3;126(10):3827-3836
pubmed: 27599292
Sci Rep. 2018 Apr 10;8(1):5750
pubmed: 29636527
J Biol Chem. 2007 May 25;282(21):15471-5
pubmed: 17409384
Blood. 2018 Apr 12;131(15):1730-1742
pubmed: 29453291
Cancer Cell. 2016 Jul 11;30(1):43-58
pubmed: 27344946
Apoptosis. 1999 Dec;4(6):455-60
pubmed: 14634330
Cancer Cell. 2012 Apr 17;21(4):473-87
pubmed: 22464800
Blood. 2011 Nov 17;118(20):5613-21
pubmed: 21937695
Lancet Oncol. 2018 Feb;19(2):216-228
pubmed: 29339097
Clin Epigenetics. 2016 May 24;8:57
pubmed: 27222667
PLoS One. 2012;7(1):e30706
pubmed: 22295105
Cancer Res. 2016 Mar 1;76(5):1158-69
pubmed: 26627013
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11872-7
pubmed: 12193648
Leukemia. 2013 Apr;27(5):1127-38
pubmed: 23212151
Nat Med. 2012 Mar 11;18(4):605-11
pubmed: 22406747
Cell Stem Cell. 2014 Jan 2;14(1):68-80
pubmed: 24239285
J Cell Biol. 2013 Nov 11;203(3):457-70
pubmed: 24217620
Cancer Cell. 2007 Aug;12(2):171-85
pubmed: 17692808
N Engl J Med. 2013 May 30;368(22):2059-74
pubmed: 23634996
Leukemia. 2013 Apr;27(4):852-60
pubmed: 23235717
Oncogene. 2001 Apr 26;20(18):2225-34
pubmed: 11402317
J Exp Med. 1995 May 1;181(5):1661-72
pubmed: 7722446
Blood. 2019 Jan 3;133(1):7-17
pubmed: 30361262
Nature. 2006 Aug 17;442(7104):818-22
pubmed: 16862118
Nat Cell Biol. 2018 Apr;20(4):413-421
pubmed: 29531308
Genome Res. 2015 May;25(5):714-24
pubmed: 25858951
Exp Hematol. 2006 May;34(5):599-609
pubmed: 16647566
Cancer Cell. 2011 Jan 18;19(1):138-52
pubmed: 21251617
J Clin Oncol. 2010 Aug 20;28(24):3890-8
pubmed: 20660833
Genes Dev. 1995 Apr 15;9(8):935-44
pubmed: 7774811
J Clin Oncol. 2013 Jan 1;31(1):95-103
pubmed: 23008312
Mol Cancer Res. 2005 Nov;3(11):627-34
pubmed: 16317088
Cell. 2018 Apr 5;173(2):291-304.e6
pubmed: 29625048
Genes Dev. 2014 Aug 15;28(16):1800-14
pubmed: 25128497
Am J Hematol. 2018 Mar;93(3):401-407
pubmed: 29218851
J Clin Oncol. 2010 Apr 20;28(12):2101-7
pubmed: 20308656
Nature. 2015 Feb 19;518(7539):360-364
pubmed: 25693567
Nat Commun. 2016 Jul 11;7:12166
pubmed: 27397025
Cell Stem Cell. 2009 Jan 9;4(1):80-93
pubmed: 19128795
J Hematol Oncol. 2016 Mar 12;9:24
pubmed: 26970896
Oncotarget. 2017 Jun 19;8(49):85085-85101
pubmed: 29156705
Cancer Res. 2016 Apr 1;76(7):1975-88
pubmed: 26837761

Auteurs

Sheng F Cai (SF)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Leukemia Service, Department of Medicine, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York.
ORCID: 0000-0002-2708-887X

S Haihua Chu (SH)

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Aaron D Goldberg (AD)

Leukemia Service, Department of Medicine, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York.
ORCID: 0000-0002-2892-2643

Salma Parvin (S)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

Richard P Koche (RP)

Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.

Jacob L Glass (JL)

Leukemia Service, Department of Medicine, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York.

Eytan M Stein (EM)

Leukemia Service, Department of Medicine, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York.

Martin S Tallman (MS)

Leukemia Service, Department of Medicine, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York.

Filiz Sen (F)

Hematopathology Diagnostic Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Christopher A Famulare (CA)

Leukemia Service, Department of Medicine, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York.

Monica Cusan (M)

University Hospital, Ludwig Maximilian University Munich, Munich, Germany.

Chun-Hao Huang (CH)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Chun-Wei Chen (CW)

Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California.
ORCID: 0000-0002-8737-6830

Lihua Zou (L)

Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.

Keith B Cordner (KB)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Nicole L DelGaudio (NL)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Vidushi Durani (V)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Mitali Kini (M)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Madison Rex (M)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Helen S Tian (HS)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
ORCID: 0000-0001-8097-1082

Johannes Zuber (J)

Research Institute of Molecular Pathology (IMP), Vienna, Austria.

Timour Baslan (T)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Scott W Lowe (SW)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Howard Hughes Medical Institute, New York, New York.
ORCID: 0000-0002-5284-9650

Hugh Y Rienhoff (HY)

Imago Biosciences, Inc., San Francisco, California.

Anthony Letai (A)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

Ross L Levine (RL)

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. scott_armstrong@dfci.harvard.edu leviner@mskcc.org.
Leukemia Service, Department of Medicine, and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York.

Scott A Armstrong (SA)

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. scott_armstrong@dfci.harvard.edu leviner@mskcc.org.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Leukemia Cell of Origin Influences Apoptotic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Régulation de l'expression des gènes dans la leucémie › Leukemia Cell of Origin Influences Apoptotic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH group donors › Oxidoreductases, (N-demethylating) › Histone Demethylases › Leukemia Cell of Origin Influences Apoptotic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Leukemia Cell of Origin Influences Apoptotic...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leukemia Cell of Origin Influences Apoptotic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Leukemia Cell of Origin Influences Apoptotic...