Association of Leukocyte Telomere Length and Genes Involved in its Regulation With Oral Carcinoma.
Relative leukocyte telomere length
gene polymorphisms
oral squamous cell carcinoma
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
15
02
2020
revised:
29
03
2020
accepted:
31
03
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
This study aimed to determine the relationship between the relative leukocyte telomere length (RLTL) and gene polymorphisms involved in its regulation with the occurrence of oral squamous cell carcinoma (OSCC). Patients with OSCC and healthy subjects were examined. Genotyping and RLTL measurement were carried out using rPCR. The OSCC group had longer telomeres than controls (p=0.001). Minor allele T at TERF1rs1545827 may increase RLTL shortening (p=0.047). TNKS2rs10509639 A/G and A/G+G/G genotypes were associated with a 2.6-fold increased odd (p=0.012) and a 2.4-fold increased odd (p=0.019) of RLTL elongation compared to A/A genotype. The A/G genotype was associated with a 2.6-fold increased odd (p=0.011) compared to the A/A+G/G genotypes. Each G allele was associated with a 2.1-fold increased odd of longer RLTL (p=0.036). Longer telomeres were found in patients with OSCC than in controls. The TERF1 rs1545827 and the TNKS2 rs10509639 polymorphisms were associated with an increase in RLTL.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
This study aimed to determine the relationship between the relative leukocyte telomere length (RLTL) and gene polymorphisms involved in its regulation with the occurrence of oral squamous cell carcinoma (OSCC).
PATIENTS AND METHODS
METHODS
Patients with OSCC and healthy subjects were examined. Genotyping and RLTL measurement were carried out using rPCR.
RESULTS
RESULTS
The OSCC group had longer telomeres than controls (p=0.001). Minor allele T at TERF1rs1545827 may increase RLTL shortening (p=0.047). TNKS2rs10509639 A/G and A/G+G/G genotypes were associated with a 2.6-fold increased odd (p=0.012) and a 2.4-fold increased odd (p=0.019) of RLTL elongation compared to A/A genotype. The A/G genotype was associated with a 2.6-fold increased odd (p=0.011) compared to the A/A+G/G genotypes. Each G allele was associated with a 2.1-fold increased odd of longer RLTL (p=0.036).
CONCLUSION
CONCLUSIONS
Longer telomeres were found in patients with OSCC than in controls. The TERF1 rs1545827 and the TNKS2 rs10509639 polymorphisms were associated with an increase in RLTL.
Identifiants
pubmed: 32606142
pii: 34/4/1739
doi: 10.21873/invivo.11967
pmc: PMC7439885
doi:
Substances chimiques
TNKS2 protein, human
EC 2.4.2.30
Tankyrases
EC 2.4.2.30
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1739-1747Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Références
Mol Diagn Ther. 2016 Aug;20(4):363-74
pubmed: 27278367
Cancer. 2013 May 15;119(10):1885-91
pubmed: 23408253
Carcinogenesis. 2010 Nov;31(11):1977-81
pubmed: 20802237
Cancer Res. 2013 Oct 1;73(19):5996-6003
pubmed: 23928994
Lab Invest. 2008 Feb;88(2):144-52
pubmed: 18158557
Lung Cancer. 2009 Nov;66(2):157-61
pubmed: 19285750
Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1238-50
pubmed: 21467229
Cancer. 2013 Dec 15;119(24):4277-83
pubmed: 24105340
Hum Mol Genet. 2014 Dec 15;23(24):6616-33
pubmed: 25027329
Cancer Prev Res (Phila). 2011 Apr;4(4):514-21
pubmed: 21460395
Cancer Res. 2014 Aug 1;74(15):4090-8
pubmed: 24853549
Front Oncol. 2012 Oct 04;2:135
pubmed: 23061048
Adv Clin Chem. 2018;86:23-70
pubmed: 30144841
EMBO Rep. 2005 Jan;6(1):39-45
pubmed: 15608617
J Dent (Shiraz). 2013 Sep;14(3):146-50
pubmed: 24724136
Int J Cancer. 2006 Nov 1;119(9):2090-7
pubmed: 16786598
Mol Med Rep. 2017 Jul;16(1):441-446
pubmed: 28535013
Gene. 2017 Dec 15;636:30-35
pubmed: 28918250
Exp Gerontol. 2007 Jul;42(7):575-81
pubmed: 17482404
Oncotarget. 2017 Oct 9;8(56):96433-96441
pubmed: 29221218
Biogerontology. 2020 Feb;21(1):57-67
pubmed: 31646401
J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8
pubmed: 12928346
Nat Genet. 2013 Apr;45(4):371-84, 384e1-2
pubmed: 23535731
FEBS Lett. 2012 Mar 23;586(6):897-904
pubmed: 22449978
Gut. 2017 Jun;66(6):1116-1122
pubmed: 27797938
Front Physiol. 2018 Apr 11;9:377
pubmed: 29695979
Ann Transl Med. 2018 Jul;6(13):280
pubmed: 30094266
Cancer. 2006 Sep 15;107(6):1391-9
pubmed: 16917952
Pathol Res Pract. 2015 Oct;211(10):766-71
pubmed: 26293798
Front Med (Lausanne). 2018 Feb 27;5:41
pubmed: 29536006
Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2642-5
pubmed: 21994403
Nat Rev Mol Cell Biol. 2010 Mar;11(3):171-81
pubmed: 20125188
Int J Mol Sci. 2019 Jun 02;20(11):
pubmed: 31159515
Head Neck. 2019 Mar;41(3):672-677
pubmed: 30589155
J Natl Cancer Inst. 2013 Apr 3;105(7):459-68
pubmed: 23468462
Eur J Cancer. 2009 Nov;45(17):3008-16
pubmed: 19766477