Implications of Low Serum Albumin as a Prognostic Factor of Long-term Outcomes in Patients With Breast Cancer.
Albumin
breast cancer
immunity
inflammation
prognosis
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
09
04
2020
revised:
18
04
2020
accepted:
20
04
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
We examined the relationship between preoperative serum albumin levels and long-term outcomes in patients with breast cancer. We retrospectively analyzed the records of 157 patients who underwent breast cancer surgery at a single institution. We divided the patients into those with <4.0 g/dl and those with ≥4.0 g/dl preoperative serum albumin. The overall median follow-up period was 86.7 months. Among the 157 patients, 19 (12.1%) had decreased serum albumin levels preoperatively. A significant association with preoperative albumin levels was found only for patient age; however, we were unable to determine an association between preoperative albumin levels and various clinical features. The recurrence-free survival (p=0.030) and the overall survival (p=0.001) were both significantly shorter in patients with low albumin levels. Low serum albumin levels were associated with poor prognosis, but not with poor-prognostic factors. Therefore, low albumin levels may reflect the tumor microenvironment in breast cancer.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
We examined the relationship between preoperative serum albumin levels and long-term outcomes in patients with breast cancer.
PATIENTS AND METHODS
METHODS
We retrospectively analyzed the records of 157 patients who underwent breast cancer surgery at a single institution. We divided the patients into those with <4.0 g/dl and those with ≥4.0 g/dl preoperative serum albumin.
RESULTS
RESULTS
The overall median follow-up period was 86.7 months. Among the 157 patients, 19 (12.1%) had decreased serum albumin levels preoperatively. A significant association with preoperative albumin levels was found only for patient age; however, we were unable to determine an association between preoperative albumin levels and various clinical features. The recurrence-free survival (p=0.030) and the overall survival (p=0.001) were both significantly shorter in patients with low albumin levels.
CONCLUSION
CONCLUSIONS
Low serum albumin levels were associated with poor prognosis, but not with poor-prognostic factors. Therefore, low albumin levels may reflect the tumor microenvironment in breast cancer.
Identifiants
pubmed: 32606178
pii: 34/4/2033
doi: 10.21873/invivo.12003
pmc: PMC7439858
doi:
Substances chimiques
Biomarkers, Tumor
0
Serum Albumin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2033-2036Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Références
Int J Colorectal Dis. 2011 Apr;26(4):473-81
pubmed: 21190025
Support Care Cancer. 1997 Sep;5(5):376-80
pubmed: 9322349
Nutr Cancer. 2017 Nov-Dec;69(8):1151-1176
pubmed: 29083236
Cancer Med. 2019 Aug;8(9):4135-4148
pubmed: 31197958
Br J Cancer. 2017 Nov 7;117(10):1572-1579
pubmed: 28898231
Nutr Cancer. 2001;39(2):210-3
pubmed: 11759282
Nutr Cancer. 1999;35(2):106-10
pubmed: 10693162
Future Oncol. 2010 Jan;6(1):149-63
pubmed: 20021215
World J Surg Oncol. 2016 Jun 27;14(1):170
pubmed: 27349744
Eur J Oncol Nurs. 2005;9 Suppl 2:S35-8
pubmed: 16437756
Eur Urol. 2011 Jun;59(6):923-8
pubmed: 21295907
Anticancer Res. 2014 Jul;34(7):3775-9
pubmed: 24982401
Int J Clin Oncol. 2020 Jan;25(1):74-81
pubmed: 31531785
JPEN J Parenter Enteral Nutr. 2003 Jan-Feb;27(1):10-5
pubmed: 12549592
Ann Surg Oncol. 2007 Feb;14(2):381-9
pubmed: 17160496
Nutr J. 2010 Dec 22;9:69
pubmed: 21176210
Nutr Cancer. 2012;64(8):1169-73
pubmed: 23163845
Lung Cancer. 2017 Sep;111:88-95
pubmed: 28838406
Anticancer Res. 2018 Aug;38(8):4927-4931
pubmed: 30061271
Mod Pathol. 1998 Feb;11(2):155-68
pubmed: 9504686