Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.

Bipolar Disorder / genetics Brain / diagnostic imaging Genetic Linkage / genetics Humans Pedigree Phenotype Quantitative Trait Loci / genetics

Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
09 2021
Historique:
received: 18 03 2019
accepted: 29 05 2020
revised: 26 05 2020
pubmed: 2 7 2020
medline: 1 2 2022
entrez: 2 7 2020
Statut: ppublish

Résumé

Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loci (QTL) that contribute to phenotypic variance of brain structure, structural neuroimages were acquired from family members (n = 527) of extended pedigrees heavily loaded for bipolar disorder ascertained from genetically isolated populations in Latin America. Genome-wide linkage and association analysis were conducted on the subset of heritable brain traits that showed significant evidence of association with bipolar disorder (n = 24) to map QTL influencing regional measures of brain volume and cortical thickness. Two chromosomal regions showed significant evidence of linkage; a QTL on chromosome 1p influencing corpus callosum volume and a region on chromosome 7p linked to cortical volume. Association analysis within the two QTLs identified three SNPs correlated with the brain measures.

Identifiants

DOI: 10.1038/s41380-020-0805-6 PMID: 32606377
pubmed: 32606377
doi: 10.1038/s41380-020-0805-6
pii: 10.1038/s41380-020-0805-6
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5229-5238

Subventions

Organisme : NIMH NIH HHS
ID : K23 MH074644
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS062691
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH075007
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095454
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG006695
Pays : United States
Organisme : NIMH NIH HHS
ID : K08 MH086786
Pays : United States

Informations de copyright

© 2020. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Scott C Fears (SC)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA. sfears@mednet.ucla.edu.
Section of Mental Health, Greater Los Angeles Veterans Administration, Los Angeles, CA, USA. sfears@mednet.ucla.edu.
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA. sfears@mednet.ucla.edu.
ORCID: 0000-0002-6443-2318

Susan K Service (SK)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.

Barbara Kremeyer (B)

Department of Genetics, Evolution and Environment, University College London, London, WC1E 6BT, UK.

Carmen Araya (C)

Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.

Xinia Araya (X)

Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.

Julio Bejarano (J)

Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.

Margarita Ramirez (M)

Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.

Gabriel Castrillón (G)

Insituto de Alta Tecnologìa Mèdica, Medellín, Colombia.

Juliana Gomez-Franco (J)

Department of Psychiatry, Harbor-UCLA Hospital, Los Angeles, CA, USA.

Maria C Lopez (MC)

Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Gabriel Montoya (G)

Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Patricia Montoya (P)

Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Ileana Aldana (I)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.

Terri M Teshiba (TM)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.

Noor B Al-Sharif (NB)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.

Maria Jalbrzikowski (M)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.

Todd A Tishler (TA)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.

Javier Escobar (J)

Department of Psychiatry and Family Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Andrés Ruiz-Linares (A)

Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, China.
UMR 7268 ADES, CNRS, Aix-Marseille Université, EFS, Faculté de médecine Timone, Marseille, 13005, France.
Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.

Carlos Lopez-Jaramillo (C)

Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Gabriel Macaya (G)

Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
ORCID: 0000-0001-5264-8691

Julio Molina (J)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
BioCiencias Lab, Guatemala, Guatemala.

Victor I Reus (VI)

Department of Psychiatry, University of California, San Francisco, CA, USA.

Rita M Cantor (RM)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Department of Human Genetics, University of California, Los Angeles, CA, USA.

Chiara Sabatti (C)

Department of Health Research and Policy, Stanford University, Stanford, CA, USA.

Nelson B Freimer (NB)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
ORCID: 0000-0003-3586-6587

Carrie E Bearden (CE)

Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
ORCID: 0000-0002-8516-923X

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › Genome-wide mapping of brain phenotypes in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Genome-wide mapping of brain phenotypes in...
questionsmedicales.fr › Phénomènes génétiques › Liaison génétique › Genome-wide mapping of brain phenotypes in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide mapping of brain phenotypes in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Pedigree › Genome-wide mapping of brain phenotypes in...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Genome-wide mapping of brain phenotypes in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Genome-wide mapping of brain phenotypes in...