Venom alkaloids against Chagas disease parasite: search for effective therapies.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 06 2020
30 06 2020
Historique:
received:
02
11
2018
accepted:
01
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Chagas disease is an important disease affecting millions of patients in the New World and is caused by a protozoan transmitted by haematophagous kissing bugs. It can be treated with drugs during the early acute phase; however, effective therapy against the chronic form of Chagas disease has yet to be discovered and developed. We herein tested the activity of solenopsin alkaloids extracted from two species of fire ants against the protozoan parasite Trypanosoma cruzi, the aetiologic agent of Chagas disease. Although IC
Identifiants
pubmed: 32606423
doi: 10.1038/s41598-020-67324-8
pii: 10.1038/s41598-020-67324-8
pmc: PMC7327076
doi:
Substances chimiques
Alkaloids
0
Arthropod Venoms
0
Trypanocidal Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10642Subventions
Organisme : FIC NIH HHS
ID : R03 TW008725
Pays : United States
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