Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy.
brain-derived neurotrophic factor
nonconvulsive electrotherapy
treatment-refractory depression
Journal
Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
03
2020
accepted:
06
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression and in the antidepressant response. This study examined whether changes in serum BDNF levels are associated with the antidepressant effects of nonconvulsive electrotherapy (NET). For BDNF analyses, serum samples were collected from 20 patients with treatment-refractory depression (TRD) and from 20 healthy controls. Serum samples were also collected from patients following a course of NET. Although significantly lower baseline serum BDNF levels were observed in TRD patients than in healthy controls, no changes in serum BDNF levels were found in TRD patients after a course of NET compared to baseline. No significant association was found between serum BDNF levels and depression severity. Serum BDNF levels appear to have no clinical utility in the prediction of the antidepressant effects of NET in patients with TRD. Future studies of higher quality and with larger sample sizes are needed to confirm these findings.
Identifiants
pubmed: 32606707
doi: 10.2147/NDT.S256278
pii: 256278
pmc: PMC7319526
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1555-1560Informations de copyright
© 2020 Zheng et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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