Effect of CXCR5-Positive Cell Infiltration on the Immune Contexture and Patient Prognosis in Head and Neck Squamous Cell Carcinoma.
CXCR5-producing cells
head and neck squamous cell carcinoma
immune contexture
prognosis
Journal
OncoTargets and therapy
ISSN: 1178-6930
Titre abrégé: Onco Targets Ther
Pays: New Zealand
ID NLM: 101514322
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
02
2020
accepted:
22
04
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
CXCR5-positive (CXCR5 The study included two patient cohorts: The Cancer Genome Atlas cohort (TCGA, n = 472) and the Renji Hospital cohort (RJHC, n = 201). The TCGA and RJHC cohorts were analyzed for CXCR5-related mRNAs and CXCR5+ cell infiltration, respectively. We then evaluated the correlation between CXCR5 mRNA and CXCR5 The 5-year overall survival rate was significantly correlated with high CXCR5 mRNA expression and CXCR5 HNSCC patients with a high intratumoral CXCR5 expression had a better prognosis than those with low intratumoral CXCR5 expression. Moreover, CXCR5
Identifiants
pubmed: 32606797
doi: 10.2147/OTT.S248958
pii: 248958
pmc: PMC7319516
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5869-5877Informations de copyright
© 2020 Chen et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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