Optimal Management of Complicated Infections in the Pediatric Patient: The Role and Utility of Ceftazidime/Avibactam.
ceftazidime/avibactam
infections
multidrug-resistant Gram-negative
pediatric
Journal
Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
10
2019
accepted:
11
02
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
Antimicrobial resistance poses a substantial threat to global public health. The pursuit of new antibiotics has decreased and very few options have been investigated for the treatment of complicated multidrug-resistant Gram-negative (MDR-GN) infections in adult population and even less in pediatric patients. Ceftazidime-avibactam (CAZ-AVI) is novel cephalosporin/β-lactamase inhibitor (BL-BLI) combination with broad antibacterial spectrum. The aim of this review is to describe the current and future role CAZ-AVI in the pediatric population with suspected or confirmed MDR-GN infections.
Identifiants
pubmed: 32606826
doi: 10.2147/IDR.S209264
pii: 209264
pmc: PMC7305847
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1763-1773Informations de copyright
© 2020 Bassetti et al.
Déclaration de conflit d'intérêts
Dr Matteo Bassetti reports grants, personal fees from Shionogi, grants, personal fees from Pfizer, grants, personal fees from MSD, personal fees from Paratek, personal fees from Astellas, grants, personal fees from Menarini, personal fees from Angelini, grants, personal fees from Tetraphase, grants, personal fees from Gilead, outside the submitted work. Dr Maddalena Peghin reports grants from Pfizer, grants from Thermofisher, outside the submitted work. The authors report no other conflicts of interest in this work.
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