Blue Mussel (
Mytilus edulis
medial meniscectomy
obesity
osteoarthritis
Journal
Journal of pain research
ISSN: 1178-7090
Titre abrégé: J Pain Res
Pays: New Zealand
ID NLM: 101540514
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
12
2019
accepted:
06
03
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
To investigate the effects of The male Sprague-Dawley rats were fed with HFD for 4 weeks before surgery. The OA rats were orally administered with MWE (108.5, 217.0, and 542.5 mg/kg) for 6 weeks. The administration of MWE affected weight loss, triglycerides content, and total cholesterol level. MWE also enhanced the activity of superoxide dismutase and decreased lipid peroxidation degree. Moreover, MWE reduced proinflammatory cytokines level, alleviated inflammation and swelling of the osteoarthritic knee, and reduced loss of proteoglycan in articular cartilage tissue. MWE suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis rats under obesity condition. Therefore, MWE has the potential to act as an alternative for osteoarthritis treatment.
Identifiants
pubmed: 32606898
doi: 10.2147/JPR.S244372
pii: 244372
pmc: PMC7293401
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1109-1119Informations de copyright
© 2020 Chang et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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