Antithyroid drugs and birth defects.
Antithyroid drugs
Birth defects
Carbimazole
Congenital malformations
Graves’ disease
Hyperthyroidism
Methimazole
Pregnancy
Propylthiouracil
Journal
Thyroid research
ISSN: 1756-6614
Titre abrégé: Thyroid Res
Pays: England
ID NLM: 101469037
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
05
2020
accepted:
18
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
Antithyroid drugs (ATDs) are preferred for the treatment of hyperthyroidism caused by Graves' disease in pregnant women. The drugs have been a recognized treatment for decades, and a general risk of side effects is known. For the use of ATDs in pregnancy, a concern about teratogenic side effects has been brought forward since the 1970s. In more recent years, a number of large observational studies have added new evidence and quantified the risk of birth defects associated with different types of ATDs. The findings that both Methimazole (MMI) and Propylthiouracil (PTU) are associated with birth defects have challenged the clinical recommendations on the treatment of hyperthyroidism in pregnancy, and certain aspects remain unclarified. In this review, the current evidence on the risk of birth defects associated with the use of ATDs in early pregnancy is described, and determinants of causality are discussed. This includes the current evidence of a biological gradient and the role of maternal thyroid function per se
Identifiants
pubmed: 32607131
doi: 10.1186/s13044-020-00085-8
pii: 85
pmc: PMC7320591
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
11Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe author declares that she has no competing interests.
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