Successful treatment of telomeropathy-related interstitial lung disease with immunosuppression and danazol.
Danazol
interstitial lung disease
non‐specific interstitial pneumonia
telomere
Journal
Respirology case reports
ISSN: 2051-3380
Titre abrégé: Respirol Case Rep
Pays: United States
ID NLM: 101631052
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
26
04
2020
revised:
08
06
2020
accepted:
09
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
We report the case of a 42-year-old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non-specific interstitial pneumonia with respiratory failure. Given a personal and family history of early greying of the hair, the peripheral blood monocyte telomere length was measured and was confirmed to be <1st centile, explaining the multiorgan presentation. She was treated with prednisolone, mycophenolate mofetil, and the synthetic androgen danazol with a dramatic improvement in respiratory failure and lung function. After 18 months of danazol treatment, the peripheral blood monocyte telomere length had returned to the normal range.
Identifiants
pubmed: 32607243
doi: 10.1002/rcr2.607
pii: RCR2607
pmc: PMC7316582
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e00607Informations de copyright
© 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
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