Plasma proteomic signatures predict dementia and cognitive impairment.
brain imaging
cognitive impairment
cognitive trajectories
dementia
proteomics
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
01
2020
accepted:
27
02
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
Biomarker discovery of dementia and cognitive impairment is important to gather insight into mechanisms underlying the pathogenesis of these conditions. In 997 adults from the InCHIANTI study, we assessed the association of 1301 plasma proteins with dementia and cognitive impairment. Validation was conducted in two Alzheimer's disease (AD) case-control studies as well as endophenotypes of AD including cognitive decline, brain amyloid burden, and brain volume. We identified four risk proteins that were significantly associated with increased odds (peptidase inhibitor 3 (PI3), trefoil factor 3 (TFF3), pregnancy associated plasma protein A (PAPPA), agouti-related peptide (AGRP)) and two protective proteins (myostatin (MSTN), integrin aVb5 (ITGAV/ITGB5)) with decreased odds of baseline cognitive impairment or dementia. Of these, four proteins (MSTN, PI3, TFF3, PAPPA) were associated cognitive decline in subjects that were cognitively normal at baseline. ITGAV/ITGB5 was associated with lower brain amyloid burden, MSTN and ITGAV/ITGB5 were associated with larger brain volume and slower brain atrophy, and PI3, PAPPA, and AGRP were associated with smaller brain volume and/or faster brain atrophy. These proteins may be useful as non-invasive biomarkers of dementia and cognitive impairment.
Identifiants
pubmed: 32607407
doi: 10.1002/trc2.12018
pii: TRC212018
pmc: PMC7210784
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12018Subventions
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States
Informations de copyright
Published 2020. This article is a U.S. Government work and is in the public domain in the USA. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
None to declare.
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