Does transient arterial-phase respiratory-motion-related artifact impact on diagnostic performance? An intra-patient comparison of extracellular gadolinium versus gadoxetic acid.
Cirrhosis
Gadoxetic acid
Liver
Magnetic resonance
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
27
01
2020
accepted:
16
06
2020
revised:
03
05
2020
pubmed:
2
7
2020
medline:
15
4
2021
entrez:
2
7
2020
Statut:
ppublish
Résumé
To compare the frequency of transient arterial-phase respiratory-motion-related artifacts in liver MRI after extracellular gadolinium and gadoxetic acid injection, and to determine the impact of these artifacts on the detection of focal areas of enhancement on arterial-phase images. Intra-patient comparison of 82 cirrhotic patients who prospectively underwent liver MR with extracellular gadolinium and with gadoxetic acid within 1 month. Two readers independently assessed the quality of dynamic T1-weighted MR images (pre-contrast, arterial, and portal-venous phases), rating respiratory-motion-related artifacts on four-point scale (0 [none]-3 [non-diagnostic]). We dichotomized these assessments, which were compared using McNemar's test, defining transient arterial-phase respiratory-motion-related artifacts as a study with a pre-contrast score < 2 and arterial-phase score ≥ 2. Readers also recorded whether at least one focal area of enhancement ≥ 10 mm on arterial phase was present. The quality of arterial-phase images was worse when obtained after gadoxetic acid than after extracellular gadolinium (p < 0.01), and transient arterial-phase respiratory-motion-related artifacts were more common after gadoxetic acid than after extracellular gadolinium (p < 0.02). At least one area of arterial-phase enhancement ≥ 10 mm was detected more often after extracellular gadolinium than after gadoxetic acid. We observed significant differences on the comparison of the distributions of the presence of arterial-phase artifacts against the presence of arterial-phase enhancement ≥ 10 mm between the two contrast agents (p < 0.0001). In cirrhotic patients, transient arterial-phase respiratory-motion-related artifacts are more common after gadoxetic acid than after extracellular gadolinium. Worse detection of arterial-phase enhancement on gadoxetic acid is only partly due to these artifacts. • In a patient-by-patient analysis, the quality of arterial-phase liver MR images was significantly worse with gadoxetic acid than with extracellular gadolinium. • The frequency of transient arterial-phase artifacts was significantly higher after gadoxetic acid injection than after extracellular gadolinium injection. • Differences in the detection of areas of arterial-phase enhancement between MRI studies done with extracellular gadolinium and those done with gadoxetic acid might not be related only to image quality.
Identifiants
pubmed: 32607632
doi: 10.1007/s00330-020-07039-6
pii: 10.1007/s00330-020-07039-6
doi:
Substances chimiques
Contrast Media
0
gadolinium ethoxybenzyl DTPA
0
Gadolinium
AU0V1LM3JT
Gadolinium DTPA
K2I13DR72L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6694-6701Références
Van Beers BE, Pastor CM, Hussain HK (2012) Primovist, Eovist: what to expect? J Hepatol 57:421–429
doi: 10.1016/j.jhep.2012.01.031
pubmed: 22504332
pmcid: 22504332
Gschwend S, Ebert W, Schultze-Mosgau M, Breuer J (2011) Pharmacokinetics and imaging properties of Gd-EOB-DTPA in patients with hepatic and renal impairment. Invest Radiol 46:556–566
doi: 10.1097/RLI.0b013e31821a218a
pubmed: 21623212
pmcid: 21623212
Roberts LR, Sirlin CB, Zaiem F et al (2018) Imaging for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis. Hepatology 67:401–421
doi: 10.1002/hep.29487
pubmed: 28859233
pmcid: 28859233
European Association for the Study of the Liver (2018) EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 69:182–236
Marrero JA, Kulik LM, Sirlin CB et al (2018) Diagnosis, staging, and management of hepatocellular carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology 68:723–750
doi: 10.1002/hep.29913
pubmed: 29624699
pmcid: 29624699
Davenport MS, Caoili EM, Kaza RK, Hussain HK (2014) Matched within-patient cohort study of transient arterial phase respiratory motion-related artifact in MR imaging of the liver: gadoxetate disodium versus gadobenate dimeglumine. Radiology 272:123–131
doi: 10.1148/radiol.14132269
pubmed: 24617733
pmcid: 24617733
Davenport MS, Al-hawary MM, Caoili EM et al (2013) Comparison of acute transient dyspnea after intravenous administration of gadoxetate disodium and gadobenate phase image quality. Radiology 266:452–461
Kim YK, Lin W-C, Sung K et al (2017) Reducing artifacts during arterial phase of gadoxetate disodium – enhanced MR imaging : dilution method versus reduced injection rate. Radiology 283:429–437
doi: 10.1148/radiol.2016160241
pubmed: 27977329
Davenport MS, Bashir MR, Pietryga JA, Weber JT, Khalatbari S, Hussain HK (2014) Dose-toxicity relationship of gadoxetate disodium and transient severe respiratory motion artifact. AJR Am J Roentgenol 203:796–802
Pietryga JA, Burke LMB, Marin D et al (2014) Phase imaging with gadoxetate disodium : examination recovery with a multiple arterial phase acquisition. Radiology 271:426–434
doi: 10.1148/radiol.13131988
pubmed: 24475864
Shah MR, Flusberg M, Paroder V, Rozenblit AM, Chernyak V (2017) Transient arterial phase respiratory motion-related artifact in MR imaging of the liver : an analysis of four different gadolinium-based contrast agents. Clin Imaging 41:23–27
Motosugi U, Bannas P, Bookwalter C, Sano K, Reeder SB (2016) An investigation of transient severe motion related to gadoxetic acid–enhanced MR imaging. Radiology 279:93–102
Sim KC, Park BJ, Han NY, Sung DJ, Kim MJ, Han YE (2019) Effects of gadoxetic acid on image quality of arterial multiphase magnetic resonance imaging of liver : comparison study with gadoteric acid - enhanced MRI. Abdom Radiol (NY). https://doi.org/10.1007/s00261-019-02202-0
Ayuso C, Forner A, Darnell A et al (2019) Prospective evaluation of gadoxetic acid magnetic resonance for the diagnosis of hepatocellular carcinoma in newly detected nodules ≤ 2 cm in cirrhosis. Liver Int 39:1281–1291
doi: 10.1111/liv.14133
pubmed: 31077539
Rimola J, Forner A, Sapena V et al (2019) Performance of gadoxetic acid MRI and diffusion-weighted imaging for the diagnosis of early recurrence of hepatocellular carcinoma. Eur Radiol 30:186–194
doi: 10.1007/s00330-019-06351-0
pubmed: 31372783
Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174
doi: 10.2307/2529310
pubmed: 843571
pmcid: 843571
Bashir MR, Castelli P, Davenport MS et al (2015) Respiratory motion artifact affecting hepatic arterial phase MR imaging with gadoxetate disodium is more common in patients with a prior episode of arterial phase motion associated with gadoxetate disodium. Radiology 274:141–148
doi: 10.1148/radiol.14140386
pubmed: 25162310
Bashir MR, Gupta RT, Davenport MS et al (2013) Hepatocellular carcinoma in a north American population : does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis ? J Magn Reson Imaging 406:398–406
doi: 10.1002/jmri.23818
Kim SY, Park SH, Wu E et al (2015) Transient respiratory motion artifact during arterial phase MRI with gadoxetate disodium: risk factor analyses. AJR Am J Roentgenol 204:1220–1227
Chernyak V, Fowler MSKJ, Kamaya A et al (2018) Liver Imaging Reporting and Data System ( LI-RADS ) version 2018 : imaging of hepatocellular carcinoma in at-risk patients. Radiology 289:816–830
doi: 10.1148/radiol.2018181494
pubmed: 30251931
pmcid: 30251931
Brismar TB, Dahlström N, Edsborg N, Persson A, Smedby O, Albiin N (2009) Liver vessel enhancement by Gd-BOPTA and Gd- EOB-DTPA : a comparison in healthy volunteers. Acta Radiol 50:709–715
Tamada T, Ito K, Sone T et al (2009) Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA. J Magn Reson Imaging 29:636–640
doi: 10.1002/jmri.21689
pubmed: 19243060
Motosugi U, Ichikawa T, Sou H et al (2009) Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging 30:1042–1046
doi: 10.1002/jmri.21956
pubmed: 19856436
Son J, Hwang SH, Park S et al (2019) Imaging features of hepatocellular carcinoma: quantitative and qualitative comparison between MRI-enhanced with Gd-EOB-DTPA and Gd-DTPA. Invest Radiol 54:494–499
doi: 10.1097/RLI.0000000000000562
pubmed: 31094878