Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study.
Antioxidant status
HIV
Hypervitaminosis A
Immunological non-response
Nutrition
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
01
03
2020
accepted:
15
06
2020
pubmed:
2
7
2020
medline:
4
5
2021
entrez:
2
7
2020
Statut:
ppublish
Résumé
For people living with HIV, determinants of immunological non-response (INR) to combined antiretroviral therapy (cART) have not been fully elucidated. In a case-control study, we evaluated the influence of the nutritional and antioxidant status in HIV-1 adults whose cART was initiated between January 2001 and December 2013. Cases had persistent CD4 counts < 350/μL vs. > 350/μL for controls, after at least 2 years of cART with persistent viral loads (VL) < 50 copies/mL. Twelve cases and twenty-eight control subjects with the same CD4 count at cART initiation were compared for their nutritional and antioxidant status after age adjustment at dosage assessment. Patients were predominantly male (70%), Caucasian (82%) and at AIDS stage (62%). The median age was 53, and the median CD4 count was 245/mm
Identifiants
pubmed: 32607910
doi: 10.1007/s10096-020-03954-0
pii: 10.1007/s10096-020-03954-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM