SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs.
Leupylogs
SAR studies
antifungal agents
natural products
total synthesis
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
26 Nov 2020
26 Nov 2020
Historique:
received:
29
05
2020
pubmed:
2
7
2020
medline:
2
7
2020
entrez:
2
7
2020
Statut:
ppublish
Résumé
Leupyrrins are highly potent antifungal agents. A structure-activity-relationship study of natural and synthetic derivatives is reported which reveals important insights into the biological relevance of several structural subunits leading to the discovery of highly potent but drastically simplified leupylogs that incorporate a stable and readily available aromatic side chain. For their synthesis a concise strategy is described that enables a short and versatile access.
Identifiants
pubmed: 32608026
doi: 10.1002/chem.202002622
pmc: PMC7756798
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15074-15078Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : TRR 261
Organisme : Deutsche Forschungsgemeinschaft
ID : ME 2756/7-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GK 850
Informations de copyright
© 2020 The Authors. Published by Wiley-VCH GmbH.
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