Pseudo-Membrane Jackets: Two-Dimensional Coordination Polymers Achieving Visible Phase Separation in Cell Membrane.

cell membranes coordination polymer metal complex lipid metal-organic framework phase separation

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
05 10 2020
Historique:
received: 07 05 2020
revised: 29 06 2020
pubmed: 2 7 2020
medline: 1 4 2021
entrez: 2 7 2020
Statut: ppublish

Résumé

Cell membranes contain lateral systems that consist of various lipid compositions and actin cytoskeleton, providing two-dimensional (2D) platforms for chemical reactions. However, such complex 2D environments have not yet been used as a synthetic platform for artificial 2D nanomaterials. Herein, we demonstrate the direct synthesis of 2D coordination polymers (CPs) at the liquid-cell interface of the plasma membrane of living cells. The coordination-driven self-assembly of networking metal complex lipids produces cyanide-bridged CP layers with metal ions, enabling "pseudo-membrane jackets" that produce long-lived micro-domains with a size of 1-5 μm. The resultant artificial and visible phase separation systems remain stable even in the absence of actin skeletons in cells. Moreover, we show the cell application of the jackets by demonstrating the enhancement of cellular calcium response to ATP.

Identifiants

pubmed: 32608036
doi: 10.1002/anie.202006600
doi:

Substances chimiques

Polymers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

17931-17937

Informations de copyright

© 2020 Wiley-VCH GmbH.

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Auteurs

Ryo Ohtani (R)

Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.

Kenichi Kawano (K)

Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.

Masanao Kinoshita (M)

Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.

Saeko Yanaka (S)

Exploratory Research Center on Life and Living Systems (ExCELLS) and Institute for Molecular Science (IMS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan.
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan.

Hikaru Watanabe (H)

Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.

Kenji Hirai (K)

Research Institute for Electronic Science, Hokkaido University, N20W10, Kita-Ward Sapporo, Hokkaido, 001-0020, Japan.

Shiroh Futaki (S)

Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.

Nobuaki Matsumori (N)

Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.

Hiroshi Uji-I (H)

Research Institute for Electronic Science, Hokkaido University, N20W10, Kita-Ward Sapporo, Hokkaido, 001-0020, Japan.
Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001, Heverlee, Belgium.

Masaaki Ohba (M)

Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.

Koichi Kato (K)

Exploratory Research Center on Life and Living Systems (ExCELLS) and Institute for Molecular Science (IMS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan.
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi, 467-8603, Japan.

Shinya Hayami (S)

Department of Chemistry, Graduate School of Science and Technology and Institute of Pulsed Power Science, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan.

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