The impact of stem cells in neuro-oncology: applications, evidence, limitations and challenges.
Journal
Acta bio-medica : Atenei Parmensis
ISSN: 2531-6745
Titre abrégé: Acta Biomed
Pays: Italy
ID NLM: 101295064
Informations de publication
Date de publication:
30 06 2020
30 06 2020
Historique:
received:
30
05
2020
accepted:
19
06
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
29
6
2021
Statut:
epublish
Résumé
Stem cells (SCs) represent a recent and attractive therapeutic option for neuro-oncology, as well as for treating degenerative, ischemic and traumatic pathologies of the central nervous system. This is mainly because of their homing capacity, which makes them capable of reaching the inaccessible SC niches of the tumor, therefore, acting as living drugs. The target of the study is a comprehensive overview of the SC-based therapies in neuro-oncology, also highlighting the current translational challenges of this type of approach. An online search of the literature was carried out on the PubMed/MEDLINE and ClinicalTrials.gov websites, restricting it to the most pertinent keywords regarding the systematization of the SCs and their therapeutic use for malignant brain tumors. A large part of the search was dedicated to clinical trials. Only preclinical and clinical data belonging to the last 5 years were shortlisted. A further sorting was implemented based on the best match and relevance. The results consisted in 96 relevant articles and 31 trials. Systematization involves a distinction between human embryonic, fetal and adult, but also totipotent, pluripotent or multipotent SCs. Mesenchymal and neuronal SCs were the most studied for neuro-oncological illnesses. 30% and 50% of the trials were phase I and II, respectively. Mesenchymal and neuronal SCs are ideal candidates for SCs-based therapy of malignant brain tumors. The spectrum of their possible applications is vast and is mainly based on the homing capacity toward the tumor microenvironment. Availability, delivery route, oncogenicity and ethical issues are the main translational challenges concerning the use of SCs in neuro-oncology.
Sections du résumé
BACKGROUND
Stem cells (SCs) represent a recent and attractive therapeutic option for neuro-oncology, as well as for treating degenerative, ischemic and traumatic pathologies of the central nervous system. This is mainly because of their homing capacity, which makes them capable of reaching the inaccessible SC niches of the tumor, therefore, acting as living drugs. The target of the study is a comprehensive overview of the SC-based therapies in neuro-oncology, also highlighting the current translational challenges of this type of approach.
METHODS
An online search of the literature was carried out on the PubMed/MEDLINE and ClinicalTrials.gov websites, restricting it to the most pertinent keywords regarding the systematization of the SCs and their therapeutic use for malignant brain tumors. A large part of the search was dedicated to clinical trials. Only preclinical and clinical data belonging to the last 5 years were shortlisted. A further sorting was implemented based on the best match and relevance.
RESULTS
The results consisted in 96 relevant articles and 31 trials. Systematization involves a distinction between human embryonic, fetal and adult, but also totipotent, pluripotent or multipotent SCs. Mesenchymal and neuronal SCs were the most studied for neuro-oncological illnesses. 30% and 50% of the trials were phase I and II, respectively.
CONCLUSION
Mesenchymal and neuronal SCs are ideal candidates for SCs-based therapy of malignant brain tumors. The spectrum of their possible applications is vast and is mainly based on the homing capacity toward the tumor microenvironment. Availability, delivery route, oncogenicity and ethical issues are the main translational challenges concerning the use of SCs in neuro-oncology.
Identifiants
pubmed: 32608375
doi: 10.23750/abm.v91i7-S.9955
pmc: PMC7975826
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-60Références
Methods Mol Biol. 2011;767:31-5
pubmed: 21822865
J Comp Neurol. 2007 Feb 20;500(6):1007-33
pubmed: 17183554
Mol Biol Cell. 2018 Nov 26;29(24):2912
pubmed: 30475100
Circ Res. 2019 Mar 15;124(6):837-839
pubmed: 30870122
Nat Rev Cancer. 2014 Oct;14(10):683-91
pubmed: 25176333
Hum Gene Ther. 2003 Dec 10;14(18):1777-85
pubmed: 14670128
Glycoconj J. 2017 Dec;34(6):691
pubmed: 29105004
Science. 1997 Apr 4;276(5309):66-71
pubmed: 9082987
Nature. 2018 Jun;558(7708):35-36
pubmed: 29872182
World Neurosurg. 2019 Jan 22;:
pubmed: 30677572
Childs Nerv Syst. 2008 Jun;24(6):773-6
pubmed: 18369643
Methods Mol Biol. 2009;482:185-97
pubmed: 19089357
Stem Cell Rev Rep. 2017 Dec;13(6):741-756
pubmed: 28812219
Hum Gene Ther. 2007 Jul;18(7):589-602
pubmed: 17630837
J Pediatr Endocrinol Metab. 2014 Jan;27(1-2):107-15
pubmed: 24025722
Clin Cancer Res. 2006 Sep 15;12(18):5550-6
pubmed: 17000692
Annu Rev Biochem. 2018 Jun 20;87:1015-1027
pubmed: 29494240
J Headache Pain. 2014 Sep 01;15:57
pubmed: 25178699
Dev Med Child Neurol. 2019 Sep;61(9):1101-1107
pubmed: 31175679
Adv Exp Med Biol. 2019;1123:71-94
pubmed: 31016596
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12846-51
pubmed: 11070094
Acta Biochim Pol. 2015;62(3):329-37
pubmed: 26200199
Cancer Res. 2008 Jul 15;68(14):5778-84
pubmed: 18632631
Turk Neurosurg. 2019;29(6):875-886
pubmed: 31452176
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Stem Cells. 2017 Jan;35(1):17-25
pubmed: 27350255
Clin Genet. 1999 Oct;56(4):267-78
pubmed: 10636444
Cell Stem Cell. 2017 Apr 6;20(4):426-428
pubmed: 28388425
Cell Transplant. 2015;24(3):339-47
pubmed: 25622293
Methods Mol Biol. 2017;1590:115-129
pubmed: 28353265
Philos Trans R Soc Lond B Biol Sci. 2002 Apr 29;357(1420):405-17
pubmed: 12028783
Prog Brain Res. 2012;201:99-117
pubmed: 23186712
Surg Neurol Int. 2017 Jun 13;8:117
pubmed: 28680736
eNeurologicalSci. 2018 Nov 27;14:31-33
pubmed: 30555950
Best Pract Res Clin Obstet Gynaecol. 2016 Feb;31:2-12
pubmed: 26602389
Heliyon. 2019 Nov 26;5(11):e02818
pubmed: 31844735
Cell Stem Cell. 2018 Jan 4;22(1):25-34
pubmed: 29304340
Cell. 2016 Nov 3;167(4):897-914
pubmed: 27814520
Cold Spring Harb Perspect Biol. 2016 May 02;8(5):
pubmed: 27048191
Sci Transl Med. 2017 Feb 1;9(375):
pubmed: 28148846
Neurotherapeutics. 2009 Jul;6(3):458-64
pubmed: 19560736
Biomed Res Int. 2015;2015:727542
pubmed: 26421301
J Transl Med. 2017 Oct 2;15(1):200
pubmed: 28969635
Stem Cells. 2008 Nov;26(11):2865-74
pubmed: 18703664
Dev Neurobiol. 2019 May;79(5):391-395
pubmed: 31219240
Biochimie. 2018 Dec;155:59-66
pubmed: 30031037
Mol Ther. 2011 Sep;19(9):1714-26
pubmed: 21629227
Nat Rev Mol Cell Biol. 2017 Mar;18(3):137
pubmed: 28144032
Oncogene. 2004 Sep 20;23(43):7150-60
pubmed: 15378075
Cell. 2018 May 17;173(5):1063-1065
pubmed: 29775587
Brain Res. 2009 May 1;1268:24-37
pubmed: 19285048
Expert Opin Biol Ther. 2015;15(9):1293-306
pubmed: 26067213
Neurologia. 2001 Mar;16(3):118-21
pubmed: 11333781
Oper Neurosurg (Hagerstown). 2018 Dec 1;15(6):E92-E93
pubmed: 29618124
Methods Mol Biol. 2007;399:199-213
pubmed: 18309934
Int J Mol Sci. 2018 Sep 17;19(9):
pubmed: 30227679
J Neurosci. 2008 Apr 23;28(17):4406-13
pubmed: 18434519
Genes Dev. 2017 Feb 15;31(4):336-346
pubmed: 28314766
Stem Cells Transl Med. 2013 Sep;2(9):655-66
pubmed: 23926209
Annu Rev Neurosci. 2009;32:149-84
pubmed: 19555289
Front Cell Neurosci. 2019 May 24;13:187
pubmed: 31178695
Methods Mol Biol. 2015;1293:v-vi
pubmed: 26236829
Stem Cells. 2006 Mar;24(3):781-92
pubmed: 16223852
J Immunol. 2015 Apr 1;194(7):3463-74
pubmed: 25712213
Cold Spring Harb Perspect Biol. 2015 Sep 01;7(9):a018812
pubmed: 26330519
Neurosurgery. 2009 Sep;65(3):610-24; discussion 624
pubmed: 19687708
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6157-E6165
pubmed: 28710334
Cell Transplant. 2000 Mar-Apr;9(2):139-52
pubmed: 10811389
Acta Med Iran. 2017 Jan;55(1):6-23
pubmed: 28188938
Nat Rev Immunol. 2017 Sep;17(9):573-590
pubmed: 28604734
Stem Cell Rev. 2006;2(2):155-62
pubmed: 17237554
J Natl Cancer Inst. 2013 Jul 3;105(13):968-77
pubmed: 23821758
Neuro Oncol. 2016 Aug;18(8):1066-78
pubmed: 27282399
Neurosci Lett. 2009 Jun 12;456(3):107-11
pubmed: 19429144
J Pediatr Surg. 2008 Nov;43(11):1998-2003
pubmed: 18970931
Anat Rec (Hoboken). 2014 Oct;297(10):1785-802
pubmed: 25125377
Br J Cancer. 2009 Apr 7;100(7):1154-64
pubmed: 19277041
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Int J Oncol. 2015 Jan;46(1):147-52
pubmed: 25310640
Arch Dis Child. 2019 Aug;104(8):768-774
pubmed: 30948362
Curr Stem Cell Res Ther. 2018;13(1):3
pubmed: 29310565
Neoplasia. 2004 Sep-Oct;6(5):490-502
pubmed: 15548357
World Neurosurg. 2019 Nov;131:10-17
pubmed: 31356977
Oxid Med Cell Longev. 2015;2015:159080
pubmed: 26294938
Oncol Lett. 2011 Mar;2(2):283-288
pubmed: 22866078
Nat Rev Genet. 2017 Jul;18(7):394
pubmed: 28529336
Science. 2015 Dec 11;350(6266):1319-20
pubmed: 26659043
Adv Exp Med Biol. 2006;557:191-220
pubmed: 16955712
Ital J Pediatr. 2018 Apr 4;44(1):44
pubmed: 29618369
Cytometry A. 2009 Jan;75(1):38-53
pubmed: 18988295
Hum Gene Ther. 2003 Sep 1;14(13):1247-54
pubmed: 12952596
Tissue Eng Part B Rev. 2014 Oct;20(5):523-44
pubmed: 24552279
Methods. 2016 Apr 15;99:37-43
pubmed: 26314280
Stem Cell Reports. 2018 May 8;10(5):1439-1441
pubmed: 29742390
Turk Neurosurg. 2018;28(3):454-461
pubmed: 28481388
Surg Neurol Int. 2019 May 10;10:76
pubmed: 31528414
Science. 2007 Dec 21;318(5858):1917-20
pubmed: 18029452
Mol Pharm. 2011 Oct 3;8(5):1559-72
pubmed: 21718006
Cell Mol Life Sci. 1998 Sep;54(9):935-45
pubmed: 9791537